Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.[5][6][8] It is taken by mouth.[8] Onset is typically within half an hour and the duration is up to 36 hours.[8]
Common side effects include headache, muscle pain, flushed skin, and nausea.[8] Caution is advised in those with cardiovascular disease.[8] Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss.[8] Tadalafil is not recommended in people taking nitrovasodilators such as nitroglycerin, as this may result in a serious drop in blood pressure.[8] Tadalafil is a PDE5 inhibitor which increases blood flow to the penis.[8] It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure.[8]
Tadalafil was approved for medical use in the United States in 2003.[8] It is available as a generic medication.[9] In 2021, it was the 171st most commonly prescribed medication in the United States, with more than 3million prescriptions.[10][11]
^"Tadalafil Use During Pregnancy". Drugs.com. 14 March 2019. Archived from the original on 1 December 2020. Retrieved 20 August 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Cite error: The named reference Cialis tadalafil PI was invoked but never defined (see the help page).
^"Cialis 10mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 26 April 2017. Archived from the original on 1 December 2020. Retrieved 20 August 2020.
^ abc"Cialis- tadalafil tablet, film coated". DailyMed. 12 June 2020. Archived from the original on 21 September 2019. Retrieved 20 August 2020.
^ ab"Adcirca- tadalafil tablet". DailyMed. 23 June 2022. Archived from the original on 6 March 2023. Retrieved 10 April 2023.
^"Cialis EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 7 January 2021. Retrieved 20 August 2020.
^ abcdefghij"Tadalafil Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 20 September 2020. Retrieved 8 April 2019.
^British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 796. ISBN 978-0-85711-338-2.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Tadalafil - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary...
dysfunction. Sildenafil and tadalafil are also indicated for the treatment of some subtypes of pulmonary hypertension, while tadalafil is also licensed for the...
treprostinil, iloprost, bosentan, ambrisentan, macitentan, and sildenafil, tadalafil, selexipag, riociguat. Lung transplantation may be an option in severe...
it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil...
Piperonal can be used in the synthesis of some pharmaceutical drugs including tadalafil, L-DOPA, and atrasentan. Piperonal has a floral odor which is commonly...
drug–drug interaction between dapoxetine and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration...
Cyanopsia also sometimes occurs as a side effect of taking sildenafil, tadalafil, or vardenafil. Cyanopsia is a medical symptom and not a sign. It is a...
there is little clinical evidence to date, as sildenafil, vardenafil, and tadalafil – sold under the brand names Viagra, Levitra and Cialis – are all based...
threshold. This effect is largely avoided by other PDE5 inhibitors, such as tadalafil. cGMP is involved in the regulation of some protein-dependent kinases...
primarily in the corpus cavernosum penis. Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset...
other biotechnology companies. Icos is best known for the development of tadalafil (Cialis), a drug used to treat erectile dysfunction. This drug was discovered...
within the PDE5 inhibitor class (which also includes avanafil, sildenafil, tadalafil, and vardenafil). Like other PDE5 inhibitors, it is used to treat erectile...
cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Sildenafil is broken down in the liver...
companies offering erection enhancement drugs like sildenafil, vardenafil, tadalafil and their generic drug equivalents through mail order. The site offers...
but may require multiple doses daily to maintain adequate urine flow. Tadalafil, a phosphodiesterase-5 inhibitor, was considered then rejected by NICE...
mononitrate and sildenafil (Viagra) or other phosphodiesterase inhibitors (Tadalafil and Udenafil) can potentiate the vasodilatory effect of isosorbide mononitrate...
symptoms, but the data is weak. PDE5 inhibitors, such as sildenafil and tadalafil, are used off-label to treat severe ischemia and ulcers in fingers and...
natural products, including safrole, and drugs and chemicals such as tadalafil, MDMA, paroxetine and piperonyl butoxide. Enzymes within the cytochrome...
inhibitors (a subset of the phosphodiesterase inhibitors) are sildenafil, tadalafil, vardenafil, and avanafil, and although all share the same mechanism of...
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