Protein-coding gene in the species Homo sapiens
PCM1 Identifiers Aliases PCM1 , PTC4, RET/PCM-1, pericentriolar material 1External IDs OMIM: 600299 MGI: 1277958 HomoloGene: 4518 GeneCards: PCM1 Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8 A4|8 23.89 cM Start 41,239,752 bp[1] End 41,332,344 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spermatocyte saccule spermatid otic placode ascending aorta aortic valve median eminence dorsomedial hypothalamic nucleus supraoptic nucleus secondary oocyte
BioGPS More reference expression data
Gene ontology Molecular function
protein binding
identical protein binding
Cellular component
ciliary basal body
cell projection
nuclear membrane
membrane
microtubule organizing center
centriole
cytoskeleton
ciliary transition zone
centrosome
centriolar satellite
pericentriolar material
cytoplasm
cytosol
apical part of cell
non-motile cilium
protein-containing complex
Biological process
positive regulation of intracellular protein transport
neuron migration
neuronal stem cell population maintenance
intraciliary transport involved in cilium assembly
cell projection organization
G2/M transition of mitotic cell cycle
cytoplasmic microtubule organization
negative regulation of neurogenesis
interkinetic nuclear migration
microtubule anchoring at centrosome
protein localization to centrosome
microtubule anchoring
social behavior
cilium assembly
ciliary basal body-plasma membrane docking
non-motile cilium assembly
centrosome cycle
regulation of G2/M transition of mitotic cell cycle
protein localization to organelle
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_006197 NM_001315507 NM_001315508
RefSeq (protein) NP_001302436 NP_001302437 NP_006188 NP_001339561 NP_001339562 NP_001339563 NP_001339564 NP_001339565 NP_001339566 NP_001339567 NP_001339568 NP_001339569 NP_001339570 NP_001339571 NP_001339572 NP_001339573 NP_001339574 NP_001339575 NP_001339576 NP_001339577 NP_001339578 NP_001339579 NP_001339580 NP_001339581 NP_001339582 NP_001339583 NP_001339584 NP_001339585 NP_001339586 NP_001339587 NP_001339588 NP_001339589 NP_001302436.1
NP_076151 NP_001390746 NP_001390748 NP_001390749 NP_001390752 NP_001390753 NP_001390754
Location (UCSC) n/a Chr 8: 41.24 – 41.33 Mb PubMed search [2] [3]
Wikidata View/Edit Human View/Edit Mouse
Pericentriolar material 1 , also known as PCM1 , is a protein which in humans is encoded by the PCM1 gene.[4] [5] [6]
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: PCM1 pericentriolar material 1".
^ Balczon R, Bao L, Zimmer WE (March 1994). "PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution". J. Cell Biol . 124 (5): 783–93. doi:10.1083/jcb.124.5.783. PMC 2119948 . PMID 8120099.
^ Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM (April 2005). "Dynamic Recruitment of Nek2 Kinase to the Centrosome Involves Microtubules, PCM-1, and Localized Proteasomal Degradation". Mol. Biol. Cell . 16 (4): 1711–24. doi:10.1091/mbc.E04-08-0688. PMC 1073654 . PMID 15659651.
Last Update: 2023-02-14T12:42:38Z
Pericentriolar material 1, also known as PCM1 , is a protein which in humans is encoded by the PCM1 gene. The PCM1 protein was originally identified by virtue...
Word Count : 1716
Last Update: 2024-03-29T06:28:23Z
aetiological base pair changes must exist within and around the PCM1 gene. The findings in relation to PCM1 support the role of DISC1 also being a susceptibility...
Word Count : 4723
Last Update: 2023-12-02T23:15:53Z
forming tissues, and the blood. The PCM1 gene codes for the PCM1 protein, i.e. pericentriolar material 1. The PCM1 protein exhibits a distinct cell cycle-dependent...
Word Count : 5760
Last Update: 2024-05-15T12:22:34Z
and CM-32P), 8 SL-JD80 PCM card/preset RAM card (JD-only) sets and 8 SO-PCM1 1-2 MB cards (both JD-800, JD-990, JV-80, JV-880, JV-90, JV-1000 and JV-1080)...
Word Count : 375
Last Update: 2024-04-25T23:11:06Z
or FGFR1 or, alternatively, a chromosome translocation that creates the PCM1 -JAK2 fusion gene. These genes code for dysfunctional protein products capable...
Word Count : 5494
Last Update: 2024-04-26T08:22:28Z
Myeloid/lymphoid neoplasms with FGFR1 rearrangement Myeloid/lymphoid neoplasms with PCM1 ―JAK2 Myelodysplastic/myeloproliferative neoplasms Chronic myelomonocytic...
Word Count : 2340
Last Update: 2024-01-04T03:42:24Z
data are available. JAK2 gene fusions with the TEL(ETV6) (TEL-JAK2) and PCM1 genes have been found in patients suffering leukemia, particularly clonal...
Word Count : 3166
Last Update: 2023-02-12T17:13:46Z
Bardet-Biedl syndrome 4 protein Lck, Proto-oncogene tyrosine-protein kinase LCK PCM1 , Pericentriolar material 1 protein TNKS, Tankyrase-1 TNKS2, Tankyrase-2 TUBE1...
Word Count : 341
Last Update: 2024-05-21T07:41:08Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 3016
Last Update: 2024-05-19T07:44:10Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 4671
Last Update: 2024-04-25T00:04:14Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 4235
Last Update: 2024-04-29T01:55:48Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 1394
Last Update: 2024-01-31T13:06:08Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 2198
Last Update: 2023-12-31T16:37:07Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 974
Last Update: 2024-05-10T22:45:07Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 2464
Last Update: 2024-04-25T14:29:26Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 3168
Last Update: 2024-04-19T19:25:25Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 3649
Last Update: 2024-05-23T16:24:37Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 2777
Last Update: 2024-04-20T07:37:29Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 2154
Last Update: 2024-04-03T19:42:49Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 2529
Last Update: 2024-02-22T06:58:08Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 7838
Last Update: 2024-03-10T00:27:19Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 3268
Last Update: 2023-02-16T07:57:59Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 195
Last Update: 2023-09-27T06:28:26Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 73
Last Update: 2024-05-10T19:26:43Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 6192
Last Update: 2024-05-06T05:02:12Z
organising proteins CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1 Microtubule severing proteins Katanin Spastin Other Tau protein Dynactin...
Word Count : 4894