Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene.[5] In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research. Although, recent genetic studies of large schizophrenia cohorts have failed to implicate DISC1 as a risk gene at the gene level,[6] the DISC1 interactome gene set was associated with schizophrenia, showing evidence from genome-wide association studies of the role of DISC1 and interacting partners in schizophrenia susceptibility.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000162946 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000043051 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, et al. (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics. 9 (9): 1415–1423. doi:10.1093/hmg/9.9.1415. hdl:20.500.11820/debc2b54-6e20-425f-9eab-dcd0c136cc98. PMID 10814723.
^Singh T, Kurki MI, Curtis D, Purcell SM, Crooks L, McRae J, et al. (April 2016). "Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders". Nature Neuroscience. 19 (4): 571–577. doi:10.1038/nn.4267. PMC 6689268. PMID 26974950.
^Facal F, Costas J (December 2019). "Evidence of association of the DISC1 interactome gene set with schizophrenia from GWAS". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 95: 109729. doi:10.1016/j.pnpbp.2019.109729. PMID 31398428. S2CID 199518630.
protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the...
illnesses. More recently, DISC1 has been associated with social anhedonia within the general population. Tomppo identified a specific DISC1 allele that is associated...
schizophrenia 1 (DISC1) was one of the first genes discovered to be involved in schizophrenia. As of 2011, seven different strains of DISC1 mouse models had...
PDE10A gene and some bipolar I disorder patients. Variants of other genes, DISC1 and GNAS, have been associated with bipolar II disorder. Autism spectrum...
domain. Activating transcription factor ATF5 has been shown to interact with DISC1 and TRIB3. GRCh38: Ensembl release 89: ENSG00000169136 – Ensembl, May 2017...
1038/s41598-018-29281-1. Hennah W, Porteous D (2009). Reif A (ed.). "The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory...
loss-of-function translocation mutation in the DISC1 gene is a major risk factor in developing schizophrenia. The DISC1 gene codes for a scaffold protein that...
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this bunch of files need?". The simple grouping can be displayed like this Disc1 -- (99%) [4,479MiB] Directory | +--- Dir1 +--- File1 Disc2 -- (98%) [4,468MiB]...
other academic journal editors. Kvajo, Mirna, et al. A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in...
video. The video was released in two volumes as Hitomi Kobayashi FINAL – Disc1 (December 19, 2003) and Disc2 (December 31, 2003). Controversy followed...
PCNT is also involved in neuronal development through its interaction with DISC1 to regulate microtubule organization. Mutations in the PCNT gene have been...
translocation found in Schizophrenia. It is antisense to the DISC1 gene and may regulate the expression of DISC1. DISC2 may also contribute to other psychiatric disorders...
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target for cancer treatment. RHOT1 has been shown to interact with: ALEX3, DISC1, Dynein, HUMMR, kinesin heavy chain (KHC), Mitofusin (MFN1/MFN2), Milton...
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involved in a schizophrenia study, relating a schizophrenia risk gene (DISC1) to a network of protein-protein interactions. This study used a two-hybrid...
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its native structural conformation. CEP63 has been shown to interact with DISC1, CEP152 and CDK1. GRCh38: Ensembl release 89: ENSG00000182923 – Ensembl...
and that a number of other genes (such as COMT, RGS4, PPP3CC, ZDHHC8, DISC1, and AKT1) showed some early promising results. Knockout studies in Drosophila...
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