Pericentriolar material (PCM, sometimes also called pericent matrix) is a highly structured,[1] dense mass of protein which makes up the part of the animal centrosome that surrounds the two centrioles. The PCM contains proteins responsible for microtubule nucleation and anchoring[2] including γ-tubulin, pericentrin and ninein.
The purple mesh represents pericentriolar material (PCM)
Although the PCM appears amorphous by electron microscopy, super-resolution microscopy finds that it is highly organized. The PCM have 9-fold symmetry that mimics the symmetry of the centriole.[citation needed] Some PCM proteins are organized such that one end of the protein is found near the centriole and the other end is farther away from the centriole.
The PCM size is dynamic during the cell cycle. After cell division, the PCM size is reduced in a process named centrosome reduction.[3] During the G2 phase of the cell cycle, the PCM grows in size in a process named centrosome maturation.
According to the Gene Ontology, the following human proteins are associated with the PCM [1]:
BBS4, Bardet-Biedl syndrome 4 protein
Lck, Proto-oncogene tyrosine-protein kinase LCK
PCM1, Pericentriolar material 1 protein
TNKS, Tankyrase-1
TNKS2, Tankyrase-2
TUBE1, Tubulin epsilon chain
PCNT,[1] pericentrin, a matrix scaffold protein
CDK5RAP2,[1] cyclin dependant kinase receptor associated protein 2, binds gTubRCs that nucleate microtubules
NEDD1,[1] binds gTubRCs that stabilise microtubules
^Atypical centrioles during sexual reproduction Tomer Avidor-Reiss*, Atul Khire, Emily L. Fishman and Kyoung H. Jo Curr Biol. 2015 Nov 16;25(22):2956-63. doi: 10.1016/j.cub.2015.09.045. Epub 2015 Oct 17. http://journal.frontiersin.org/article/10.3389/fcell.2015.00021/full
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up of a pair of centrioles at its center, and is surrounded by pericentriolarmaterial (PCM) that is important for microtubule nucleation. Microtubules...
The sperm centriole, found near the male pronucleus, recruit egg Pericentriolarmaterial proteins forming the zygote first centrosome. This centrosome nucleates...
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vesicle-mediated transport Golgi organization regulation of transcription, DNA-templated protein localization to pericentriolarmaterial Sources:Amigo / QuickGO...
centrosome throughout the cell cycle, being distributed in the pericentriolarmaterial. CEP135 is required for the centriolar localization of CEP250....
Fong KW, Choi YK, Rattner JB, Qi RZ (January 2008). "CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin...
cytoplasm microtubule organizing center spindle pole nucleolus pericentriolarmaterial microtubule cytoskeleton mitotic spindle pole microtubule minus-end...
is hard to classify; it has a distinctive ultrastructure of its pericentriolarmaterial. Molecular evidence places it in the Amoebozoa. It has been suggested...
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