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arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
neurophysin II, Bos taurus
Identifiers
Symbol
AVP
Alt. symbols
ARVP
NCBI gene
551
HGNC
894
OMIM
192340
RefSeq
NM_000490
UniProt
P01185
Other data
Locus
Chr. 20 p13
Search for
Structures
Swiss-model
Domains
InterPro
Neurophysin II is a carrier protein with a size of 19,687.3 Da and is made up of a dimer of two virtually identical chains of amino acids. Neurophysin II is a cleavage product (formed by splitting of a compound molecule into a simpler one) of the AVP gene. It is a neurohypophysial hormone that is transported in vesicles with vasopressin, the other cleavage product, along axons, from magnocellular neurons of the hypothalamus to the posterior lobe of the pituitary. Although it is stored in neurosecretory granules with vasopressin and released with vasopressin into the bloodstream, its biological action is unclear. Neurophysin II is also known as a stimulator of prolactin secretion.
NeurophysinII is a carrier protein with a size of 19,687.3 Da and is made up of a dimer of two virtually identical chains of amino acids. Neurophysin...
neurosecretory granules, the analogous neurophysin I and II form stabilizing complexes via covalent interactions. Stabilizing neurophysin-hormone complexes that are...
of the posterior pituitary. Neurophysin I neurons are more prevalent in the paraventricular nuclei while NeurophysinII neurons are more prevalent in...
contains ATP and a type of neurophysin. Neurophysins are binding proteins, of which there are two types: neurophysin I and neurophysinII, which bind to oxytocin...
derived from the C-terminus of pre-pro-hormone of arginine vasopressin, neurophysinII and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic...
calcium channels in neurohypophyseal nerve terminals in rats. Angiotensin II stimulates AVP secretion, in keeping with its general pressor and pro-volumic...
"Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20". Molecular...
to produce vasopressin (also known as antidiuretic hormone or ADH), neurophysinII, and a glycoprotein called copeptin. AVP and other AVP-like peptides...
form of DI is due to an inherited mutation of the arginine vasopressin-neurophysinII (AVP-NPII) gene, inherited in an autosomal dominant manner. At one point...
type II synapses are flattened. The material on the presynaptic and post-synaptic membranes is denser in a Type I synapse than it is in a Type II, and...
synthesized as a preprohormone that includes a second peptide, neurophysin VT (neurophysins are carrier proteins that are secreted along with their passenger...
hypothalamo-neurohypophyseal tract with the help of the carrier protein, neurophysin I, to the pars nervosa of the posterior pituitary, and then stored in...
Omeclamox, and Ethyol. Hepatoren, Boxban, Vasculan, and currently in phase II clinical trials. Protaban, Methotrexate, and Totect are waiting for pre-approval...
Scrivens, James H.; Elphick, Maurice R. (2013). "Discovery of a novel neurophysin-associated neuropeptide that triggers cardiac stomach contraction and...
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