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Demeclocycline information


Demeclocycline
demeclocycline 2D skeletal
demeclocycline 3D BS
Clinical data
Trade namesDeclomycin
Other namesRP-10192, demethylchlortetracycline
AHFS/Drugs.comMonograph
MedlinePlusa682103
Routes of
administration		Oral
ATC code
  • D06AA01 (WHO) J01AA01 (WHO)
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability60–80%
Protein binding41–50%
MetabolismHepatic
Elimination half-life10–17 hours
ExcretionRenal
Identifiers
IUPAC name
  • (2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione
CAS Number
  • 127-33-3 checkY
    64-73-3 (HCl)
PubChem CID
  • 54680690
DrugBank
  • DB00618 checkY
ChemSpider
  • 10482117 checkY
UNII
  • 5R5W9ICI6O
KEGG
  • D03680 checkY
ChEBI
  • CHEBI:4392 checkY
ChEMBL
  • ChEMBL1591 checkY
CompTox Dashboard (EPA)
  • DTXSID1022893 Edit this at Wikidata
ECHA InfoCard100.004.396 Edit this at Wikidata
Chemical and physical data
FormulaC21H21ClN2O8
Molar mass464.86 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • NC(=O)C1C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@H]2C(C=1O)N(C)C
InChI
  • InChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31)/t6-,7-,14-,15-,21-/m0/s1 checkY
  • Key:FMTDIUIBLCQGJB-SEYHBJAFSA-N checkY
  (verify)

Demeclocycline (INN, BAN, USAN, brand name Declomycin) is a tetracycline antibiotic which was derived from a mutant strain of Streptomyces aureofaciens.[1][2]

  1. ^ Chopra I, Hawkey PM, Hinton M (March 1992). "Tetracyclines, molecular and clinical aspects". The Journal of Antimicrobial Chemotherapy. 29 (3): 245–277. doi:10.1093/jac/29.3.245. PMID 1592696.
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 356–. ISBN 978-1-4757-2085-3.

and 26 Related for: Demeclocycline information

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Demeclocycline

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Demeclocycline (INN, BAN, USAN, brand name Declomycin) is a tetracycline antibiotic which was derived from a mutant strain of Streptomyces aureofaciens...

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Vasopressin receptor antagonist

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Mozavaptan Satavaptan Tolvaptan Somatostatin is a competitive inhibitor. Demeclocycline, a tetracycline antibiotic, is sometimes used to block the action of...

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Aquaretic

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vasopressin receptor antagonists and include conivaptan, tolvaptan, demeclocycline, and mozavaptan (OPC-31260), as well as lithium. Conivaptan hydrochloride...

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Syndrome of inappropriate antidiuretic hormone secretion

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3–4 h may be given. Demeclocycline can be used in chronic situations when fluid restrictions are difficult to maintain; demeclocycline is the most potent...

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Nephrotoxicity

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Amphotericin B—reversible at low doses, irreversible at high doses Fluoride Demeclocycline Foscarnet Lead, Uranium, mercury, and cadmium salts Aristolochic acid...

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Timeline of antibiotics

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phenoxymethylpenicillin 1958 – colistin, the first polymyxin 1958 – demeclocycline 1959 – virginiamycin 1960 – methicillin 1960 – metronidazole, the first...

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Primary polydipsia

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risperidone Demeclocycline, a tetracycline antibiotic, which is effective due to the side effect of inducing nephrogenic diabetes insipidus. Demeclocycline is...

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Vasopressin

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antidepressants and fludrocortisone may raise the diuretic effect lithium, demeclocycline, heparin or norepinephrine may lower the antidiuretic effect vasopressor...

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Tetracycline antibiotics

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tetracyclines (plain tetracycline, chlortetracycline, oxytetracycline, demeclocycline and methacycline) be taken with a full glass of water, either two hours...

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Hyponatremia

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insufficiently responsive to fluid restriction and/or sodium tablets. Demeclocycline, while sometimes used for SIADH, has significant side effects including...

Word Count : 4313

Mechanism of action

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Acamprosate Antidepressants Armodafinil Cannabidiol Cyclobenzaprine Demeclocycline Fabomotizole Lithium Meprobamate Methocarbamol Paracetamol Phenytoin...

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List of antibiotics

Last Update:

Septra Sulfonamidochrysoidine (archaic) Prontosil Tetracyclines(Bs) Demeclocycline Declomycin Syphilis, chlamydial infections, Lyme disease, mycoplasmal...

Word Count : 747

Oxytocin

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Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

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Tetracycline

Last Update:

(FL): StatPearls Publishing. PMID 31751095. Retrieved 2024-03-19. "Demeclocycline", LiverTox: Clinical and Research Information on Drug-Induced Liver...

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Atosiban

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Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

Word Count : 1724

Desmopressin

Last Update:

Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

Word Count : 1518

Lithium carbonate

Last Update:

Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

Word Count : 2631

Tolvaptan

Last Update:

Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

Word Count : 763

ATC code D06

Last Update:

codes not present in this list, which follows the WHO version. D06AA01 Demeclocycline D06AA02 Chlortetracycline D06AA03 Oxytetracycline D06AA04 Tetracycline...

Word Count : 303

Carbetocin

Last Update:

Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

Word Count : 1913

California Proposition 65 list of chemicals

Last Update:

50-29-3 o,p'-DDT 789-02-6 p,p'-DDT 50-29-3 DDVP (Dichlorvos) 62-73-7 Demeclocycline hydrochloride 64-73-3 Des-ethyl atrazine (DEA) 6190-65-4 Des-isopropyl...

Word Count : 211

Oxytocin receptor agonist

Last Update:

Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

Word Count : 264

Terlipressin

Last Update:

Unsorted Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)...

Word Count : 584

ATC code J01

Last Update:

codes not present in this list, which follows the WHO version. J01AA01 Demeclocycline J01AA02 Doxycycline J01AA03 Chlortetracycline J01AA04 Lymecycline J01AA05...

Word Count : 1151

Hypotonic hyponatremia

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SIADH is reduction of water intake. If hyponatremia persists, then demeclocycline (an antibiotic with the side effect of inhibiting ADH) can be used....

Word Count : 750

Vasopressin receptor 2

Last Update:

however these agents should be avoided in patients with cirrhosis. Demeclocycline and lithium carbonate act as indirect antagonists of renal vasopressin...

Word Count : 1740
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