cysteine-type endopeptidase inhibitor activity involved in apoptotic process
neurohypophyseal hormone activity
signaling receptor binding
V1A vasopressin receptor binding
V1B vasopressin receptor binding
neuropeptide hormone activity
Cellular component
extracellular region
cytosol
clathrin-coated vesicle membrane
extracellular space
secretory granule
dendrite
Biological process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
vasoconstriction
negative regulation of release of cytochrome c from mitochondria
ERK1 and ERK2 cascade
water transport
cell-cell signaling
negative regulation of apoptotic process
protein kinase C signaling
generation of precursor metabolites and energy
positive regulation of peptidyl-serine phosphorylation
positive regulation of gene expression
renal water homeostasis
signal transduction
apoptotic process
membrane organization
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
maternal aggressive behavior
positive regulation of systemic arterial blood pressure
positive regulation of cytosolic calcium ion concentration
negative regulation of female receptivity
grooming behavior
locomotory behavior
positive regulation of cell population proliferation
positive regulation of glutamate secretion
response to organic cyclic compound
positive regulation of cell growth
positive regulation of prostaglandin biosynthetic process
positive regulation of cellular pH reduction
response to testosterone
response to nicotine
social behavior
regulation of renal sodium excretion
hyperosmotic salinity response
maternal behavior
penile erection
response to ethanol
positive regulation of vasoconstriction
multicellular organismal water homeostasis
negative regulation of transmission of nerve impulse
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
551
11998
Ensembl
ENSG00000101200
ENSMUSG00000037727
UniProt
P01185
P35455
RefSeq (mRNA)
NM_000490
NM_009732
RefSeq (protein)
NP_000481
NP_033862
Location (UCSC)
Chr 20: 3.08 – 3.08 Mb
Chr 2: 130.42 – 130.42 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The arginine vasopressin gene (AVP) is a gene whose product is proteolytically cleaved to produce vasopressin (also known as antidiuretic hormone or ADH), neurophysin II, and a glycoprotein called copeptin. AVP and other AVP-like peptides are found in mammals, as well as mollusks, arthropods, nematodes, and other invertebrate species.[5] In humans, AVP is present on chromosome 20 and plays a role in homeostatic regulation. The products of AVP have many functions that include vasoconstriction, regulating the balance of water in the body, and regulating responses to stress.[6] Expression of AVP is regulated by the transcription translation feedback loop (TTFL), which is an important part of the circadian system that controls the expression of clock genes. AVP has important implications in the medical field as its products have significant roles throughout body.
preproAVP
Diagram of the pre-pro-AVP precursor showing position and size in amino acids of vasopressin, neurophysin II and copeptin
Identifiers
Symbol
preproAVP
OMIM
192340
UniProt
P01185
Other data
Locus
Chr. 20 p13
Search for
Structures
Swiss-model
Domains
InterPro
^ abcGRCh38: Ensembl release 89: ENSG00000101200 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037727 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Albers HE (January 2015). "Species, sex and individual differences in the vasotocin/vasopressin system: relationship to neurochemical signaling in the social behavior neural network". Frontiers in Neuroendocrinology. 36: 49–71. doi:10.1016/j.yfrne.2014.07.001. PMC 4317378. PMID 25102443.
^Ryckmans T (September 2010). "Modulation of the vasopressin system for the treatment of CNS diseases". Current Opinion in Drug Discovery & Development. 13 (5): 538–47. PMID 20812145.
The arginine vasopressin gene (AVP) is a gene whose product is proteolytically cleaved to produce vasopressin (also known as antidiuretic hormone or ADH)...
vasopressin (AVP) or argipressin, is a hormone synthesized from the AVPgene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It...
and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic hormone (ADH), is encoded by the AVPgene and is involved in multiple cardiovascular...
oscillating gene, such as the AVPgene, is rhythmic but not necessary to the pacemaker. The first recorded observations of oscillating genes come from the...
(formed by splitting of a compound molecule into a simpler one) of the AVPgene. It is a neurohypophysial hormone that is transported in vesicles with...
Vasopressin is produced from the vasopressin-producing cells via the AVPgene, a molecular output of circadian pathways.[citation needed] Magnocellular...
Central diabetes insipidus, recently renamed arginine vasopressin deficiency (AVP-D), is a form of diabetes insipidus that is due to a lack of vasopressin...
elucidating and synthesizing oxytocin and vasopressin via manipulating the AVPgene, he had established a reputation from his research on insulin, biotin,...
causes a reduced occupancy of MeCP2 at the AVPgene's promoter region, and therefore elevated levels of AVP. Vasopressin is a primary hormone involved...
"Inactivation of the oxytocin and the vasopressin (Avp) 1b receptor genes, but not the Avp 1a receptor gene, differentially impairs the Bruce effect in laboratory...
[NALP3] and cryopyrin), is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1. NLRP3 is expressed predominantly...
László FA (1984). "Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of...
Quadrilogy, 2003, 20th Century Fox Gillis, Alec & Woodruff, Tom (2004). AVP: Alien vs. Predator: The Creature Effects of ADI. London: Titan Books. p...
venom protein. Additionally to these VSTs, other accessory venom proteins (AVPs) were also found to be highly expressed in the venom gland such as: cobra...
and the dopamine-mediated reward pathway. Peptide arginine vasopressin (AVP), dopamine, and oxytocin act in this region to coordinate rewarding activities...
BMAL1 knockout VIP neurons but not AVP neurons with an increase in the mean vector r in VIP neurons but not in AVP neurons. Raleigh plots or variations...
The most abundant peptides found within the SCN are arginine-vasopressin (AVP), vasoactive intestinal polypeptide (VIP), and peptide histidine-isoleucine...
in the respective countries. A nasal spray form of sumatriptan known as AVP-825 has been developed by Avanir and is generically available in some countries...
Peak's development. Dynamic Attractions originally committed to building the AVP Coaster system for a lump sum of $34 million. Track for the SFX Coaster first...
psychiatric disorders. The combination drug dextromethorphan/quinidine (AVP-923), traditionally used to treat pseudobulbar affect, is under investigation...
chain is a protein that in humans is encoded by the IFNAR1 gene. The protein encoded by this gene is a type I membrane protein that forms one of the two chains...
Burnatowska-Hledin MA, Spielman WS, Smith WL, et al. (1995). "Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medulla". Am J...
diabetes insipidus, recently renamed as arginine vasopressin resistance (AVP-R) and also previously known as renal diabetes insipidus, is a form of diabetes...
clothes, and racquet bags. Wilson is the official ball supplier of the AVP. In 2021, Wilson developed a brand partnership with Crossnet.[citation needed]...