Neurophysins are carrier proteins which transport the hormones oxytocin and vasopressin to the posterior pituitary from the paraventricular and supraoptic nucleus of the hypothalamus, respectively. Inside the neurosecretory granules, the analogous neurophysin I and II form stabilizing complexes via covalent interactions.[1] Stabilizing neurophysin-hormone complexes that are formed within neurosecretory granules located in the posterior pituitary gland aid in intra-axonal transport.[2] During intra-axonal transport, the neurophysin's are believed to prevent the bound hormone from leaking into the cytoplasmic space and proteolytic digestion via enzymes.[3] However, due to the low concentration of neurophysin in the blood, it is likely the protein-hormone complex dissociates, indicating the neurophysin does not aid in transporting the hormone through the circulatory system.[2]
Neurophysins are also secreted out of the posterior pituitary hypothalamus, each carrying their respective associated passenger hormone. When the posterior pituitary hypothalamus secretes vasopressin and its neurophysin carrier, it also secretes a glycopeptide.
There are two types:
Neurophysin I - Oxytocin
Neurophysin II - Vasopressin (Also known as "antidiuretic hormone" or ADH)
^Airaodion AI, Ekenjoku JA, Ogbuagu EO, Okoroukwu VN, Ogbuagu U (2019-10-22). "Carica papaya Leaves Might Cause Miscarriage". Asian Research Journal of Gynaecology and Obstetrics: 1–9.
^ abBreslow E (June 1979). "Chemistry and biology of the neurophysins". Annual Review of Biochemistry. 48 (1): 251–74. doi:10.1146/annurev.bi.48.070179.001343. PMID 382985.
^Breslow E (June 1979). "Chemistry and biology of the neurophysins". Annual Review of Biochemistry. 48 (1): 251–74. doi:10.1146/annurev.bi.48.070179.001343. PMID 382985.
Neurophysins are carrier proteins which transport the hormones oxytocin and vasopressin to the posterior pituitary from the paraventricular and supraoptic...
hydrophobic amino acids and undergo analogous binding to neurophysins. The amino acid sequence of Neurophysin I is: NH2 - Ala - Ala - Pro - Asp - Leu - Asp - Val...
are hydrophobic amino acids and undergo analogous binding to neurophysins. Neurophysin II is a dimer with each monomer consisting of two anti-parallel...
contains ATP and a type of neurophysin. Neurophysins are binding proteins, of which there are two types: neurophysin I and neurophysin II, which bind to oxytocin...
carrier protein neurophysin I. The inactive precursor protein is progressively hydrolyzed into smaller fragments (one of which is neurophysin I) via a series...
1jk4: DES 1-6 BOVINE NEUROPHYSIN II COMPLEX WITH VASOPRESSIN 1jk6: UNCOMPLEXED DES 1-6 BOVINE NEUROPHYSIN 1npo: BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN...
Scrivens, James H.; Elphick, Maurice R. (2013). "Discovery of a novel neurophysin-associated neuropeptide that triggers cardiac stomach contraction and...
derived from the C-terminus of pre-pro-hormone of arginine vasopressin, neurophysin II and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic...
hypothalamo-neurohypophyseal tract with the help of the carrier protein, neurophysin I, to the pars nervosa of the posterior pituitary, and then stored in...
protein OTOR: encoding protein Otoraplin OXT: encoding protein Oxytocin/neurophysin i prepropeptide PANK2: pantothenate kinase 2 (pantothenate kinase-associated...
"Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors". Biochimie. 70 (9): 1197–1207. doi:10.1016/0300-9084(88)90185-X...
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