NPR2 information

NPR2
Identifiers
Aliases	NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2, GCB, AMD1, GC-B
External IDs	OMIM: 108961; MGI: 97372; HomoloGene: 2970; GeneCards: NPR2; OMA:NPR2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,809,732 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,651,244 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; anterior pituitary; ; canal of the cervix; ; ascending aorta; ; Descending thoracic aorta; ; body of uterus; ; stromal cell of endometrium; ; left uterine tube; ; muscle layer of sigmoid colon;
	Top expressed in
	neural layer of retina; ; soleus muscle; ; ankle; ; skin of external ear; ; extraocular muscle; ; muscle of thigh; ; median eminence; ; cumulus cell; ; spinal ganglia; ; tunica media of zone of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase activity; nucleotide binding; hormone binding; GTP binding; lyase activity; identical protein binding; phosphorus-oxygen lyase activity; ATP binding; guanylate cyclase activity; natriuretic peptide receptor activity; peptide hormone binding; protein binding; adenylate cyclase activity; peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; guanylate cyclase complex, soluble; integral component of plasma membrane; intracellular anatomical structure;
Biological process	negative regulation of meiotic cell cycle; regulation of cardiac conduction; intracellular signal transduction; ossification; negative regulation of oocyte maturation; cyclic nucleotide biosynthetic process; regulation of blood pressure; cGMP biosynthetic process; protein phosphorylation; cellular response to granulocyte macrophage colony-stimulating factor stimulus; bone development; receptor guanylyl cyclase signaling pathway; reproductive process; positive regulation of cGMP-mediated signaling; cGMP-mediated signaling; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4882
	230103
	ENSG00000159899
	ENSMUSG00000028469
	P20594
	Q6VVW5
	NM_000907; NM_003995; NM_001378923
	NM_173788; NM_001355466
	NP_003986; NP_001365852
	NP_776149; NP_001342395
	Wikidata
View/Edit Human	View/Edit Mouse

Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic peptide receptor which in humans is encoded by the NPR2 gene.^[5]

A mutation in the NPR2 gene can result in achondroplasia and disproportionate dwarfism with short limbs.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159899 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028469 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)".
^ Tsuji T, Kunieda T (April 2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse". The Journal of Biological Chemistry. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159899 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028469 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)".

[6] Tsuji T, Kunieda T (April 2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse". The Journal of Biological Chemistry. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353.

NPR2 information

and 25 Related for: NPR2 information

NPR2

Dwarfism

Lemborexant

Oogenesis

Aripiprazole

Acromesomelic dysplasia

Brexpiprazole

Cyclase

Riluzole

Lurasidone

Atrial natriuretic peptide

Suvorexant

Depressant

Transition metal pincer complex

Resumption of meiosis

Atrial natriuretic peptide receptor

DEPDC5

Organophosphine

Tonotopy

Laurinda Jaffe

NPRL2

Protein kinase domain

List of OMIM disorder codes

Antipsychotics abuse

NPR3