cellular response to granulocyte macrophage colony-stimulating factor stimulus
bone development
receptor guanylyl cyclase signaling pathway
reproductive process
positive regulation of cGMP-mediated signaling
cGMP-mediated signaling
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4882
230103
Ensembl
ENSG00000159899
ENSMUSG00000028469
UniProt
P20594
Q6VVW5
RefSeq (mRNA)
NM_000907 NM_003995 NM_001378923
NM_173788 NM_001355466
RefSeq (protein)
NP_003986 NP_001365852
NP_776149 NP_001342395
Location (UCSC)
Chr 9: 35.79 – 35.81 Mb
Chr 4: 43.63 – 43.65 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic peptide receptor which in humans is encoded by the NPR2 gene.[5]
A mutation in the NPR2 gene can result in achondroplasia and disproportionate dwarfism with short limbs.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000159899 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028469 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tsuji T, Kunieda T (April 2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse". The Journal of Biological Chemistry. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353.
Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic...
Hypogonadotropic hypogonadism may cause proportionate, yet temporary, dwarfism. NPR2 disproportionate dwarfism was discovered recently and is caused by a mutant...
maintains meiotic arrest. The cyclic GMP is produced by the guanylyl cyclase NPR2. As follicles grow, they acquire receptors for luteinizing hormone, a pituitary...
a protein that affects bone development, natriuretic peptide receptor B (Npr2). This is a receptor for the hormone C-type natriuretic peptide which is...
cyclase-B (GC-B) also known as natriuretic peptide receptor-B (NPRB/ANPB) or NPR2 natriuretic peptide clearance receptor (NPRC/ANPC) or NPR3 NPR-A and NPR-B...
to aid in binding to two protein partners, Npr2 and Npr3. Together, these three proteins form the Iml1-Npr2-Npr3 complex and are involved in "non-nitrogen...
present the granulosa cells, in particular, natriuretic peptide receptor 2 (NPR2) and natriuretic peptide precursor-C (NPPC) that can be found in the cumulus...
derived from long-chain ditertiary phosphines, species of the type R2P(CH2)nPR2 where n >4 and R = tert-butyl. Platinum metalates one methylene group with...
specific frequencies. Research has suggested that the receptor guanylyl cyclase Npr2 is vital for the precise and specific organization of this tonotopy. Further...
1035–43. doi:10.1016/j.peptides.2004.08.035. PMID 15911071. S2CID 28281513. NPR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings...
growth. Hormonal signalling decreases the amount of cGMP by inactivating NPR2. In the ovaries, this causes the cGMP to resume meiotic function, whilst...