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NPR2 information


NPR2
Identifiers
AliasesNPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2, GCB, AMD1, GC-B
External IDsOMIM: 108961; MGI: 97372; HomoloGene: 2970; GeneCards: NPR2; OMA:NPR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000907
NM_003995
NM_001378923

NM_173788
NM_001355466

RefSeq (protein)

NP_003986
NP_001365852

NP_776149
NP_001342395

Location (UCSC)Chr 9: 35.79 – 35.81 MbChr 4: 43.63 – 43.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic peptide receptor which in humans is encoded by the NPR2 gene.[5]

A mutation in the NPR2 gene can result in achondroplasia and disproportionate dwarfism with short limbs.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159899 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028469 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)".
  6. ^ Tsuji T, Kunieda T (April 2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse". The Journal of Biological Chemistry. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353.

and 25 Related for: NPR2 information

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NPR2

Last Update:

Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic...

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Dwarfism

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Hypogonadotropic hypogonadism may cause proportionate, yet temporary, dwarfism. NPR2 disproportionate dwarfism was discovered recently and is caused by a mutant...

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Lemborexant

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A review". Neuropsychopharmacology Reports. 41 (4): 450–458. doi:10.1002/npr2.12205. PMC 8698673. PMID 34553844. "Lemborexant". Specialist Pharmacy Service...

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Oogenesis

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maintains meiotic arrest. The cyclic GMP is produced by the guanylyl cyclase NPR2. As follicles grow, they acquire receptors for luteinizing hormone, a pituitary...

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Aripiprazole

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brexpiprazole". Neuropsychopharmacology Reports. 41 (2): 134–143. doi:10.1002/npr2.12180. PMC 8340839. PMID 33960741. Roth BL, Driscol J. "PDSP Ki Database"...

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Acromesomelic dysplasia

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a protein that affects bone development, natriuretic peptide receptor B (Npr2). This is a receptor for the hormone C-type natriuretic peptide which is...

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Brexpiprazole

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brexpiprazole". Neuropsychopharmacology Reports. 41 (2): 134–143. doi:10.1002/npr2.12180. PMC 8340839. PMID 33960741. Stahl SM (February 2016). "Mechanism of...

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Lurasidone

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case report". Neuropsychopharmacology Reports. 42 (3): 377–379. doi:10.1002/npr2.12259. PMC 9515717. PMID 35609885. British national formulary: BNF 76 (76 ed...

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Riluzole

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systematic review". Neuropsychopharmacology Reports. 43 (3): 320–327. doi:10.1002/npr2.12364. PMC 10496048. PMID 37463744. Grant P, Song JY, Swedo SE (August 2010)...

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Atrial natriuretic peptide

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cyclase-B (GC-B) also known as natriuretic peptide receptor-B (NPRB/ANPB) or NPR2 natriuretic peptide clearance receptor (NPRC/ANPC) or NPR3 NPR-A and NPR-B...

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Suvorexant

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antagonists: A review". Neuropsychopharmacol Rep. 41 (4): 450–458. doi:10.1002/npr2.12205. PMC 8698673. PMID 34553844. Uchiyama M, Kambe D, Imadera Y, Kajiyama...

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Cyclase

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GUCY1B3 Guanylate cyclase 2C Guanylate cyclase 2D Guanylate cyclase 2F NPR1 NPR2 Protein cyclase, a ligase enzyme that produces backbone-cyclised proteins...

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Depressant

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literature review". Neuropsychopharmacology Reports. 41 (3): 434–439. doi:10.1002/npr2.12195. ISSN 2574-173X. PMC 8411313. PMID 34382380. Hellwig, Thaddaus R.;...

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DEPDC5

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to aid in binding to two protein partners, Npr2 and Npr3. Together, these three proteins form the Iml1-Npr2-Npr3 complex and are involved in "non-nitrogen...

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Resumption of meiosis

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present the granulosa cells, in particular, natriuretic peptide receptor 2 (NPR2) and natriuretic peptide precursor-C (NPPC) that can be found in the cumulus...

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Atrial natriuretic peptide receptor

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guanylate cyclase B (atrionatriuretic peptide receptor B) Identifiers Symbol NPR2 Alt. symbols ANPRB, NPRB NCBI gene 4882 HGNC 7944 OMIM 108961 RefSeq NM_003995...

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Transition metal pincer complex

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derived from long-chain ditertiary phosphines, species of the type R2P(CH2)nPR2 where n >4 and R = tert-butyl. Platinum metalates one methylene group with...

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Tonotopy

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specific frequencies. Research has suggested that the receptor guanylyl cyclase Npr2 is vital for the precise and specific organization of this tonotopy. Further...

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Organophosphine

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trimethylphosphine (triphenylphosphine does not react). Diphosphines, R2PPR2, R2P(CH2)nPR2 Phosphine oxide, R3P=O Phosphorane, PR5, R3P=CR2 Phosphinite, P(OR)R2 Phosphonite...

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NPRL2

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NPRL2 Identifiers Aliases NPRL2, NPR2, NPR2L, TUSC4, NPR2-like, GATOR1 complex subunit, FFEVF2, NPR2 like, GATOR1 complex subunit External IDs OMIM: 607072;...

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List of OMIM disorder codes

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Hunter-Thompson type; 201250; GDF5 Acromesomelic dysplasia, Maroteaux type; 602875; NPR2 Action myoclonus-renal failure syndrome; 254900; SCARB2 Acyl-CoA dehydrogenase...

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Protein kinase domain

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NEK2 ; NEK3 ; NEK4 ; NEK5 ; NEK6 ; NEK7 ; NEK8 ; NEK9 ; NIM1K ; NLK ; NPR1 ; NPR2 ; NRBP1 ; NRBP2 ; NRK ; NTRK1 ; NTRK2 ; NTRK3 ; NUAK1 ; NUAK2 ; OBSCN ; OXSR1 ;...

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Antipsychotics abuse

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retrospective study". Neuropsychopharmacology Reports. 43 (3): 434–439. doi:10.1002/npr2.12372. ISSN 2574-173X. PMC 10496068. PMID 37574802. Merino, Diane; Gérard...

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NPR3

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1035–43. doi:10.1016/j.peptides.2004.08.035. PMID 15911071. S2CID 28281513. NPR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings...

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Laurinda Jaffe

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growth. Hormonal signalling decreases the amount of cGMP by inactivating NPR2. In the ovaries, this causes the cGMP to resume meiotic function, whilst...

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