dentate gyrus of hippocampal formation granule cell
secondary oocyte
nucleus of stria terminalis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
protein kinase activity
protein binding
GTPase activator activity
Cellular component
GATOR1 complex
lysosome
lysosomal membrane
membrane
Biological process
negative regulation of TOR signaling
cellular response to amino acid starvation
negative regulation of kinase activity
positive regulation of GTPase activity
protein phosphorylation
cellular response to nitrogen starvation
positive regulation of autophagy
regulation of autophagosome assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10641
56032
Ensembl
ENSG00000114388
ENSMUSG00000010057
UniProt
Q8WTW4
Q9WUE4
RefSeq (mRNA)
NM_006545
NM_018879
RefSeq (protein)
NP_006536
NP_061367
Location (UCSC)
Chr 3: 50.35 – 50.35 Mb
Chr 9: 107.42 – 107.42 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000114388 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000010057 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.
regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene. GRCh38: Ensembl...
two highly conserved complexes: the "GATOR1" complex containing DEPDC5, NPRL2 and NPRL3 and the ""GATOR2" complex containing Mios, WDR24, WDR59, Seh1L...
function ascribed to Nprl3 to date is as part of the GATOR1 complex (with NPRL2 and DEPDC5) that inhibits the mechanistic target of rapamycin (mTOR) kinase-complex-1...
and the transcription factor MYC. DEPDC5 is in the "GATOR1" complex with NPRL2 and NPRL3. GRCh38: Ensembl release 89: ENSG00000100150 – Ensembl, May 2017...