DEPDC5 information

DEPDC5
Identifiers
Aliases	DEPDC5, DEP.5, FFEVF, DEP domain containing 5, FFEVF1, DEP domain containing 5, GATOR1 subcomplex subunit
External IDs	OMIM: 614191; MGI: 2141101; HomoloGene: 34718; GeneCards: DEPDC5; OMA:DEPDC5 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,908,033 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	33,151,580 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; frontal pole; ; middle frontal gyrus; ; epithelium of colon; ; Brodmann area 10; ; ventricular zone; ; sural nerve; ; testicle; ; mucosa of transverse colon; ; Achilles tendon;
	Top expressed in
	spermatocyte; ; lumbar subsegment of spinal cord; ; tail of embryo; ; spermatid; ; lumbar spinal ganglion; ; yolk sac; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-containing complex binding; GTPase activator activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; GATOR1 complex; cytosol; lysosome; lysosomal membrane; membrane; Cul3-RING ubiquitin ligase complex; intracellular anatomical structure;
Biological process	negative regulation of TOR signaling; cellular response to amino acid starvation; intracellular signal transduction; positive regulation of GTPase activity; negative regulation of TORC1 signaling; regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	9681
	277854
	ENSG00000100150
	ENSMUSG00000037426
	O75140
	P61460
NM_001007188; NM_001136029; NM_001242896; NM_001242897; NM_014662;
	NM_001363852; NM_001363854; NM_001364318; NM_001364319; NM_001364320; NM_001369901; NM_001369902; NM_001369903
	NM_001025426; NM_001170567; NM_177786; NM_001360014
NP_001007189; NP_001129501; NP_001229825; NP_001229826; NP_055477;
	NP_001350781; NP_001350783; NP_001351247; NP_001351248; NP_001351249; NP_001356830; NP_001356831; NP_001356832
NP_001020597; NP_001164038; NP_808454; NP_001346943; NP_001391242;
	NP_001391243; NP_001391244; NP_001391245; NP_001391246; NP_001391247; NP_001391248; NP_001391249; NP_001391261; NP_001391262; NP_001391263; NP_001391264; NP_001391265
	Wikidata
View/Edit Human	View/Edit Mouse

DEPDC5 (or DEP domain-containing 5) is a human protein of poorly understood function but has been associated with cancer in several studies.^[5]^[6] It is encoded by a gene of the same name, located on chromosome 22.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037426 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miki D, Ochi H, Hayes CN, et al. (August 2011). "Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers". Nat. Genet. 43 (8): 797–800. doi:10.1038/ng.876. PMID 21725309. S2CID 205357903.
^ Seng TJ, Ichimura K, Liu L, Tingby O, Pearson DM, Collins VP (June 2005). "Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis". Genes Chromosomes Cancer. 43 (2): 181–93. doi:10.1002/gcc.20181. PMID 15770670. S2CID 45003453.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100150 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037426 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[one-5] Miki D, Ochi H, Hayes CN, et al. (August 2011). "Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers". Nat. Genet. 43 (8): 797–800. doi:10.1038/ng.876. PMID 21725309. S2CID 205357903.

[two-6] Seng TJ, Ichimura K, Liu L, Tingby O, Pearson DM, Collins VP (June 2005). "Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis". Genes Chromosomes Cancer. 43 (2): 181–93. doi:10.1002/gcc.20181. PMID 15770670. S2CID 45003453.

DEPDC5 information

and 5 Related for: DEPDC5 information

DEPDC5

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C12orf66