negative regulation of transcription by RNA polymerase II
chromatin organization
transcription by RNA polymerase II
regulation of cysteine-type endopeptidase activity involved in apoptotic process
adenohypophysis development
transcription, DNA-templated
neuronal stem cell population maintenance
positive regulation of transcription, DNA-templated
multicellular organism development
glial cell fate commitment
response to wounding
osteoblast differentiation
positive regulation of cell differentiation
negative regulation of epithelial cell proliferation
regulation of gene expression
inner ear development
forebrain development
response to growth factor
negative regulation of canonical Wnt signaling pathway
positive regulation of MAPK cascade
positive regulation of transcription by RNA polymerase II
cytokine-mediated signaling pathway
cell differentiation
cell fate commitment
central nervous system development
neuron differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6657
20674
Ensembl
ENSG00000181449
ENSMUSG00000074637
UniProt
P48431
P48432
RefSeq (mRNA)
NM_003106
NM_011443
RefSeq (protein)
NP_003097
NP_035573
Location (UCSC)
Chr 3: 181.71 – 181.71 Mb
Chr 3: 34.7 – 34.71 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.[5]
Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.[5]
Sox2 holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000181449 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000074637 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"SOX2". NCBI.
^Rizzino A (2009). "Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells". Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1 (2): 228–236. doi:10.1002/wsbm.12. PMC 2794141. PMID 20016762.
as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has...
anophthalmia is mutated SOX2 gene. Sox2 anophthalmia syndrome is caused by a mutation in the Sox2 gene that does not allow it to produce the Sox2 protein that regulates...
in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription...
pluripotent cells. Virally induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create pluripotent (iPS)...
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies...
factors: Sox2 and Oct4 proteins. These transcription factors cause the pluripotent mouse embryonic stem cells to select a germ layer fate. Sox2 promotes...
pioneered in 2006 using mouse fibroblasts and four transcription factors, Oct4, Sox2, Klf4 and c-Myc; this technique, called reprogramming, later earned Shinya...
early embryo, but could in the end reduce it to 4 transcription factors – Sox2, Oct4, Klf4 and c-Myc. The 2012 Nobel Prize in Physiology or Medicine was...
treatment upon reflux of a large excess of thionyl chloride or thionyl bromide (SOX2) in the presence of a small amount of a nitrogen base, such as a tertiary...
pluripotent stem cells are generated by the transcription factors Myc, Oct3/4, Sox2, and Klf4. Sophie M. Worobec (2008). "Treatment of leprosy/Hansen's disease...
do not turn on the Cdx2 gene, and express high levels of Oct4, Nanog, and Sox2. These genes suppress Cdx2 and the inside cells maintain pluripotency generate...
Halibut is located on chromosome 9 and it is likely to be bmpr1ba. The gene sox2 is likely to play the same role in the Greenland Halibut. The North Pacific...
with Sox2 for the expression of FGF4 which could aid in differentiation. Sox2 is a gene used in maintaining pluripotency in stem cells. Oct4 and Sox2 work...
factors and cell surface proteins. The transcription factors Oct-4, Nanog, and Sox2 form the core regulatory network that ensures the suppression of genes that...
group) DNA-binding domain and functions primarily in neurogenesis. SOX1, SOX2 and SOX3, members of the SOX gene family (specifically the SOXB1 group),...
cells to return to a 'stem-like' state alongside transcription factors Oct4, Sox2 and Klf4. It has since been shown that it is possible to generate iPSCs without...
expressed or induced in bird feet, such as the scale-feather converters Sox2, Zic1, Grem1, Spry2, and Sox18. Feathers and scales are made up of two distinct...
The VZ and SVZ are indicated by immunohistochemical labelling of Sox2 and Tbr2 gene expression in the embryonic mouse forebrain at embryonic day 13.5....
Global Information
