Notch 1 information

NOTCH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA
Identifiers
Aliases	NOTCH1, Notch1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, AOS5, AOVD1, hN1, notch 1, notch receptor 1
External IDs	OMIM: 190198; MGI: 97363; HomoloGene: 32049; GeneCards: NOTCH1; OMA:NOTCH1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,546,048 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,406,675 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; external globus pallidus; ; ganglionic eminence; ; blood; ; superficial temporal artery; ; vulva; ; sural nerve; ; oral cavity; ; nipple; ; lower lobe of lung;
	Top expressed in
	hair follicle; ; conjunctival fornix; ; renal corpuscle; ; skin of back; ; lip; ; utricle; ; right lung; ; primitive streak; ; corneal stroma; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; DNA-binding transcription factor activity; Notch binding; enzyme inhibitor activity; metal ion binding; enzyme binding; chromatin binding; protein binding; sequence-specific DNA binding; protein heterodimerization activity; chromatin DNA binding; transmembrane signaling receptor activity; signaling receptor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; membrane; adherens junction; extracellular region; nucleus; cell surface; apical plasma membrane; endoplasmic reticulum; integral component of membrane; Golgi apparatus; receptor complex; plasma membrane; nucleoplasm; MAML1-RBP-Jkappa- ICN1 complex; cell periphery; endoplasmic reticulum membrane; Golgi membrane; acrosomal vesicle; cytoplasmic vesicle;
Biological process	cardiac vascular smooth muscle cell development; endoderm development; pulmonary valve morphogenesis; positive regulation of endothelial cell differentiation; regulation of somitogenesis; cell differentiation in spinal cord; negative regulation of neuron differentiation; regulation of extracellular matrix assembly; distal tubule development; negative regulation of glial cell proliferation; epithelial to mesenchymal transition involved in endocardial cushion formation; regulation of transcription by RNA polymerase II; aortic valve morphogenesis; oligodendrocyte differentiation; endocardium morphogenesis; negative regulation of osteoblast differentiation; negative regulation of stem cell differentiation; negative regulation of ossification; heart looping; negative regulation of photoreceptor cell differentiation; arterial endothelial cell differentiation; atrioventricular valve morphogenesis; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; humoral immune response; foregut morphogenesis; negative regulation of oligodendrocyte differentiation; positive regulation of cardiac muscle cell proliferation; regulation of developmental process; mesenchymal cell development; animal organ regeneration; angiogenesis; spermatogenesis; negative regulation of pro-B cell differentiation; regulation of cardioblast proliferation; hair follicle morphogenesis; vasculogenesis involved in coronary vascular morphogenesis; negative regulation of canonical Wnt signaling pathway; regulation of neurogenesis; negative regulation of cell population proliferation; collecting duct development; positive regulation of neuroblast proliferation; cilium assembly; heart trabecula morphogenesis; atrioventricular node development; negative regulation of myoblast differentiation; cell fate commitment; regulation of transcription, DNA-templated; cellular response to follicle-stimulating hormone stimulus; lung development; negative regulation of inner ear auditory receptor cell differentiation; cardiac septum morphogenesis; ventricular septum morphogenesis; negative regulation of cell differentiation; coronary artery morphogenesis; response to muramyl dipeptide; cardiac left ventricle morphogenesis; in utero embryonic development; negative regulation of cell death; endocardial cell differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; heart development; prostate gland epithelium morphogenesis; embryonic limb morphogenesis; growth involved in heart morphogenesis; neural tube development; pericardium morphogenesis; epidermis development; cardiac atrium morphogenesis; transcription initiation from RNA polymerase II promoter; cardiac right atrium morphogenesis; negative regulation of cell-substrate adhesion; cell migration involved in endocardial cushion formation; cell differentiation; venous endothelial cell differentiation; regulation of inner ear auditory receptor cell differentiation; negative regulation of catalytic activity; inflammatory response to antigenic stimulus; positive regulation of astrocyte differentiation; positive regulation of epithelial cell proliferation; cardiac right ventricle formation; endocardial cushion development; cell fate specification; positive regulation of keratinocyte differentiation; positive regulation of glial cell differentiation; negative regulation of neurogenesis; glomerular mesangial cell development; sprouting angiogenesis; glial cell differentiation; negative regulation of transcription by RNA polymerase II; cardiac muscle cell proliferation; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; positive regulation of epithelial to mesenchymal transition; ventricular trabecula myocardium morphogenesis; neuronal stem cell population maintenance; negative regulation of cell migration involved in sprouting angiogenesis; response to lipopolysaccharide; compartment pattern specification; immune response; neuron differentiation; epithelial to mesenchymal transition; positive regulation of BMP signaling pathway; skeletal muscle cell differentiation; regulation of gene expression; positive regulation of viral genome replication; regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of transcription, DNA-templated; cardiac ventricle morphogenesis; branching morphogenesis of an epithelial tube; positive regulation of receptor signaling pathway via JAK-STAT; negative regulation of anoikis; Notch signaling involved in heart development; coronary vein morphogenesis; apoptotic process involved in embryonic digit morphogenesis; regulation of cell migration; axonogenesis; tissue regeneration; positive regulation of cell migration; somatic stem cell division; cardiac muscle tissue morphogenesis; negative regulation of endothelial cell chemotaxis; keratinocyte differentiation; negative regulation of BMP signaling pathway; endocardial cushion morphogenesis; endocardium development; multicellular organism development; auditory receptor cell fate commitment; response to corticosteroid; tube formation; determination of left/right symmetry; astrocyte differentiation; negative regulation of calcium ion-dependent exocytosis; brain development; regulation of cell population proliferation; positive regulation of cell population proliferation; negative regulation of myotube differentiation; positive regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; mitral valve formation; liver development; cardiac chamber formation; forebrain development; cellular response to vascular endothelial growth factor stimulus; neuron fate commitment; regulation of epithelial cell proliferation; regulation of Notch signaling pathway; left/right axis specification; positive regulation of transcription by RNA polymerase II; cardiac epithelial to mesenchymal transition; embryonic hindlimb morphogenesis; positive regulation of aorta morphogenesis; venous blood vessel morphogenesis; Notch signaling pathway; negative regulation of gene expression; negative regulation of growth rate; positive regulation of Ras protein signal transduction; positive regulation of ERK1 and ERK2 cascade; positive regulation of transcription of Notch receptor target; positive regulation of Notch signaling pathway; outflow tract morphogenesis; coronary sinus valve morphogenesis; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of extracellular matrix constituent secretion; negative regulation of cardiac muscle hypertrophy; positive regulation of gene expression; homeostasis of number of cells within a tissue; negative regulation of biomineral tissue development; positive regulation of apoptotic process involved in morphogenesis; positive regulation of cardiac epithelial to mesenchymal transition; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4851
	18128
	ENSG00000148400
	ENSMUSG00000026923
	P46531
	Q01705
	NM_017617
	NM_008714
	NP_060087
	NP_032740
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenic locus notch homolog protein 1 (Notch 1) is a protein encoded in humans by the NOTCH1 gene.^[5] Notch 1 is a single-pass transmembrane receptor.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148400 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026923 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "NOTCH1 - Neurogenic locus notch homolog protein 1 precursor - Homo sapiens (Human) - NOTCH1 gene & protein". www.uniprot.org. Retrieved 23 May 2022.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148400 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026923 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] "NOTCH1 - Neurogenic locus notch homolog protein 1 precursor - Homo sapiens (Human) - NOTCH1 gene & protein". www.uniprot.org. Retrieved 23 May 2022.

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