negative regulation of cell population proliferation
negative regulation of fat cell differentiation
cell-cell junction organization
regulation of transcription, DNA-templated
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
signal transduction involved in regulation of gene expression
in utero embryonic development
negative regulation of transforming growth factor beta receptor signaling pathway
nodal signaling pathway
positive regulation of transcription, DNA-templated
negative regulation of cell growth
regulation of immune response
positive regulation of transforming growth factor beta3 production
T cell activation
activin receptor signaling pathway
regulation of striated muscle tissue development
embryonic foregut morphogenesis
positive regulation of bone mineralization
wound healing
negative regulation of apoptotic process
positive regulation of extracellular matrix assembly
negative regulation of transcription by RNA polymerase II
positive regulation of epithelial to mesenchymal transition
mitigation of host defenses by virus
thyroid gland development
developmental growth
lens fiber cell differentiation
gastrulation
immune response
osteoblast differentiation
primary miRNA processing
negative regulation of osteoblast proliferation
osteoblast development
embryonic cranial skeleton morphogenesis
transdifferentiation
paraxial mesoderm morphogenesis
response to hypoxia
positive regulation of cell migration
mesoderm formation
regulation of transforming growth factor beta receptor signaling pathway
positive regulation of gene expression
immune system development
positive regulation of focal adhesion assembly
liver development
regulation of epithelial cell proliferation
positive regulation of stress fiber assembly
positive regulation of transcription by RNA polymerase II
negative regulation of mitotic cell cycle
negative regulation of cytosolic calcium ion concentration
canonical Wnt signaling pathway
protein stabilization
transcription, DNA-templated
negative regulation of protein catabolic process
protein deubiquitination
positive regulation of nitric oxide biosynthetic process
negative regulation of lung blood pressure
positive regulation of pri-miRNA transcription by RNA polymerase II
negative regulation of cardiac muscle hypertrophy in response to stress
cellular response to transforming growth factor beta stimulus
cellular response to cytokine stimulus
positive regulation of protein import into nucleus
positive regulation of DNA-binding transcription factor activity
SMAD protein signal transduction
positive regulation of canonical Wnt signaling pathway
SMAD protein complex assembly
adrenal gland development
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4088
17127
Ensembl
ENSG00000166949
ENSMUSG00000032402
UniProt
P84022
Q8BUN5
RefSeq (mRNA)
NM_001145102 NM_001145103 NM_001145104 NM_005902
NM_016769
RefSeq (protein)
NP_001138574 NP_001138575 NP_001138576 NP_005893
NP_058049
Location (UCSC)
Chr 15: 67.06 – 67.2 Mb
Chr 9: 63.55 – 63.67 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.[5][6]
SMAD3 is a member of the SMAD family of proteins. It acts as a mediator of the signals initiated by the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death.[7][8] Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.
^ abcGRCh38: Ensembl release 89: ENSG00000166949 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032402 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: SMAD3 SMAD family member 3".
^Zhang Y, Feng X, We R, Derynck R (September 1996). "Receptor-associated Mad homologues synergize as effectors of the TGF-beta response". Nature. 383 (6596): 168–172. Bibcode:1996Natur.383..168Z. doi:10.1038/383168a0. PMID 8774881. S2CID 4306019.
^Massagué J (1998). "TGF-beta signal transduction". Annual Review of Biochemistry. 67 (1): 753–791. doi:10.1146/annurev.biochem.67.1.753. PMID 9759503.
^Moustakas A, Souchelnytskyi S, Heldin CH (December 2001). "Smad regulation in TGF-beta signal transduction". Journal of Cell Science. 114 (Pt 24): 4359–4369. doi:10.1242/jcs.114.24.4359. PMID 11792802.
and 28 Related for: Mothers against decapentaplegic homolog 3 information
Mothersagainstdecapentaplegichomolog3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is...
SMAD4, also called SMAD family member 4, Mothersagainstdecapentaplegichomolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein...
Mothersagainstdecapentaplegichomolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the SMAD9 gene. SMAD9, as its...
Mothersagainstdecapentaplegichomolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. SMAD7 is a protein that, as its name describes...
in decapentaplegic fail to form these structures correctly, hence the name (decapenta-, fifteen, -plegic, paralysis). Dpp is the Drosophila homolog of...
Microphthalmia-associated transcription factor, and Mothersagainstdecapentaplegichomolog3 A proportion of renal carcinomas (RCC) that occur in young...
been shown to interact with CDC27, Mothersagainstdecapentaplegichomolog3 and Mothersagainstdecapentaplegichomolog 2. GRCh38: Ensembl release 89: ENSG00000164162...
has been shown to interact with Mothersagainstdecapentaplegichomolog 7 and Mothersagainstdecapentaplegichomolog3. GRCh38: Ensembl release 89: ENSG00000157450...
17q23.3-q24.1. SMURF2 has been shown to interact with: Mothersagainstdecapentaplegichomolog 1, Mothersagainstdecapentaplegichomolog 2, Mothers against...
independent validation. CEBPD has been shown to interact with Mothersagainstdecapentaplegichomolog3. Ccaat-enhancer-binding proteins GRCh38: Ensembl release...
has been shown to interact with: AXIN1, DVL3, EPS8, and Mothersagainstdecapentaplegichomolog3. Dishevelled GRCh38: Ensembl release 89: ENSG00000107404...
also known as HSPC123-like protein (HSPC123L) and wound inducible transcript 3.0 (wit3.0). The Homo sapiens FGFR1OP2 gene is located on chromosome 12, with...