Mouse model of colorectal and intestinal cancer information
Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated, fed a modified diet, or challenged with chemicals to develop malignancies in the gastrointestinal tract. These models enable researchers to study the onset, progression of the disease, and understand in depth the molecular events that contribute to the development and spread of colorectal cancer. They also provide a valuable biological system, to simulate human physiological conditions, suitable for testing therapeutics.[1][2][3]
^Golovko, D; Kedrin, D; Yilmaz, ÖH; Roper, J (2015). "Colorectal cancer models for novel drug discovery". Expert Opinion on Drug Discovery. 10 (11): 1217–29. doi:10.1517/17460441.2015.1079618. PMC 4872297. PMID 26295972.
^Oh, BY; Hong, HK; Lee, WY; Cho, YB (28 February 2017). "Animal models of colorectal cancer with liver metastasis". Cancer Letters. 387: 114–120. doi:10.1016/j.canlet.2016.01.048. PMID 26850374.
^Evans, JP; Sutton, PA; Winiarski, BK; Fenwick, SW; Malik, HZ; Vimalachandran, D; Tweedle, EM; Costello, E; Palmer, DH; Park, BK; Kitteringham, NR (February 2016). "From mice to men: Murine models of colorectal cancer for use in translational research". Critical Reviews in Oncology/Hematology. 98: 94–105. doi:10.1016/j.critrevonc.2015.10.009. PMID 26558688.
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solid tumours in both humans and murine models. Increased numbers of regulatory T cells in breast, colorectaland ovarian cancers is associated with a poorer...
the European vs US trials of bevacizumab in colorectalcancer: Tyagi and Grothey, Clin ColorectalCancer, 2006).[citation needed] As an anti-angiogenic...
differentiation of colorectalcancer cells. Sox2 has been shown to be relevant in the development of Tamoxifen resistance in breast cancer. In Glioblastoma...
transplanted to mouse intestines, and are hence highly regarded as a valuable model for research. One of the fields of research that intestinal organoids have...
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colorectal cancer cells provided evidence that TCF7L2 played a role in proliferation and metastasis ofcancer cells in colorectalcancer. Variants of the gene...
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