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Models of DNA evolution information


A number of different Markov models of DNA sequence evolution have been proposed.[1] These substitution models differ in terms of the parameters used to describe the rates at which one nucleotide replaces another during evolution. These models are frequently used in molecular phylogenetic analyses. In particular, they are used during the calculation of likelihood of a tree (in Bayesian and maximum likelihood approaches to tree estimation) and they are used to estimate the evolutionary distance between sequences from the observed differences between the sequences.

  1. ^ Arenas, Miguel (2015). "Trends in substitution models of molecular evolution". Frontiers in Genetics. 6: 319. doi:10.3389/fgene.2015.00319. ISSN 1664-8021. PMC 4620419. PMID 26579193.

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Models of DNA evolution

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A number of different Markov models of DNA sequence evolution have been proposed. These substitution models differ in terms of the parameters used to...

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Substitution model

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substitution model, also called models of sequence evolution, are Markov models that describe changes over evolutionary time. These models describe evolutionary...

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Molecular models of DNA

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interactions of DNA. Whereas molecular models of DNA molecules such as closely packed spheres (CPK models) made of plastic or metal wires for skeletal models are...

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Molecular phylogenetics

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one-parameter model, and the Kimura two-parameter model (see Models of DNA evolution). The fourth stage consists of various methods of tree building,...

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Outline of evolution

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of evolution – Organism as host plus microbe community Models of DNA evolution – Mathematical models of changing DNA Molecular evolution – Process of...

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Multiregional origin of modern humans

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multiregional evolution (MRE), or polycentric hypothesis, is a scientific model that provides an alternative explanation to the more widely accepted "Out of Africa"...

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Molecular evolution

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Molecular evolution describes how inherited DNA and/or RNA change over evolutionary time, and the consequences of this for proteins and other components of cells...

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UPGMA

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clustering Models of DNA evolution Molecular clock Sokal, Michener (1958). "A statistical method for evaluating systematic relationships". University of Kansas...

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Human evolution

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Human evolution is the evolutionary process within the history of primates that led to the emergence of Homo sapiens as a distinct species of the hominid...

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Evolution

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molecular evolution literature. For instance, mutation biases are frequently invoked in models of codon usage. Such models also include effects of selection...

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Gene duplication

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evolution. It can be defined as any duplication of a region of DNA that contains a gene. Gene duplications can arise as products of several types of errors...

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Molecular clock

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Mitochondrial Eve and Y-chromosomal Adam Models of DNA evolution Molecular evolution Neutral theory of molecular evolution Glottochronology Zuckerkandl E, Pauling...

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DNA

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Deoxyribonucleic acid (/diːˈɒksɪˌraɪboʊnjuːˌkliːɪk, -ˌkleɪ-/ ; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form...

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Infinite sites model

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Infinite sites model (ISM) is a mathematical model of molecular evolution first proposed by Motoo Kimura in 1969. Like other mutation models, the ISM provides...

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Viral evolution

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chance of mutations and evolution can change depending on the type of virus (e.g., double stranded DNA, double stranded RNA, single strand DNA), viruses...

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Outline of machine learning

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Intelligence Michael Kearns (computer scientist) MinHash Mixture model Mlpy Models of DNA evolution Moral graph Mountain car problem Movidius Multi-armed bandit...

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Introduction to evolution

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In biology, evolution is the process of change in all forms of life over generations, and evolutionary biology is the study of how evolution occurs. Biological...

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Substitution matrix

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pyrimidine or vice versa (A ↔ C, A ↔ T, G ↔ C, and G ↔ T). Models of DNA evolution Substitution model Zvelebil, Marketa J. (2008). Understanding bioinformatics...

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Stochastic matrix

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kernel, the equivalent of a stochastic matrix over a continuous state space Matrix difference equation Models of DNA evolution Muirhead's inequality Probabilistic...

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Markov chain

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examples include: Phylogenetics and bioinformatics, where most models of DNA evolution use continuous-time Markov chains to describe the nucleotide present...

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Mitochondrial DNA

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Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food...

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Population genetics

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field work. Population genetic models are used both for statistical inference from DNA sequence data and for proof/disproof of concept. What sets population...

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DNA methylation

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hormone therapy. DNA methylation can also be detected by computational models through sophisticated algorithms and methods. Computational models can facilitate...

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Mutation

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sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral...

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Timeline of human evolution

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timeline of human evolution outlines the major events in the evolutionary lineage of the modern human species, Homo sapiens, throughout the history of life...

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Distance matrices in phylogeny

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substitution matrix such as that derived from the Jukes–Cantor model of DNA evolution. The least-squares criterion applied to these distances is more...

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Human mitochondrial DNA haplogroup

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genome database. List of mtDNA haplogroup projects at ISOGG. Rishishwar L, Jordan IK (2017). "Implications of human evolution and admixture for mitochondrial...

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DNA polymerase

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precursors of DNA. These enzymes are essential for DNA replication and usually work in groups to create two identical DNA duplexes from a single original DNA duplex...

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