Process in which chromosomes are replicated and separated into two new identical nuclei
For the type of cell division in sexually reproducing organisms used to produce gametes, see Meiosis. For excessive constriction of the pupils, see Miosis. For the parasitic infestation, see Myiasis. For muscle inflammation, see Myositis.
Mitosis in the animal cell cycle (phases ordered counter-clockwise).Mitosis divides the chromosomes in a cell nucleus.Label-free live cell imaging of mesenchymal stem cells undergoing mitosisOnion cells in different phases of the cell cycle enlarged 800 diameters. a. non-dividing cells b. nuclei preparing for division (spireme-stage) c. dividing cells showing mitotic figures e. pair of daughter-cells shortly after division
Mitosis (/maɪˈtoʊsɪs/) is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis is an equational division which gives rise to genetically identical cells in which the total number of chromosomes is maintained.[1] Mitosis is preceded by the S phase of interphase (during which DNA replication occurs) and is followed by telophase and cytokinesis, which divide the cytoplasm, organelles, and cell membrane of one cell into two new cells containing roughly equal shares of these cellular components.[2] The different stages of mitosis altogether define the mitotic phase (M phase) of a cell cycle—the division of the mother cell into two daughter cells genetically identical to each other.[3]
The process of mitosis is divided into stages corresponding to the completion of one set of activities and the start of the next. These stages are preprophase (specific to plant cells), prophase, prometaphase, metaphase, anaphase, and telophase. During mitosis, the chromosomes, which have already duplicated during interphase, condense and attach to spindle fibers that pull one copy of each chromosome to opposite sides of the cell.[4] The result is two genetically identical daughter nuclei. The rest of the cell may then continue to divide by cytokinesis to produce two daughter cells.[5] The different phases of mitosis can be visualized in real time, using live cell imaging.[6]
An error in mitosis can result in the production of three or more daughter cells instead of the normal two. This is called tripolar mitosis and multipolar mitosis, respectively. These errors can be the cause of non-viable embryos that fail to implant.[7] Other errors during mitosis can induce mitotic catastrophe, apoptosis (programmed cell death) or cause mutations. Certain types of cancers can arise from such mutations.[8]
Mitosis occurs only in eukaryotic cells and varies between organisms.[9] For example, animal cells generally undergo an open mitosis, where the nuclear envelope breaks down before the chromosomes separate, whereas fungal cells generally undergo a closed mitosis, where chromosomes divide within an intact cell nucleus.[10][11] Most animal cells undergo a shape change, known as mitotic cell rounding, to adopt a near spherical morphology at the start of mitosis. Most human cells are produced by mitotic cell division. Important exceptions include the gametes – sperm and egg cells – which are produced by meiosis. Prokaryotes, bacteria and archaea which lack a true nucleus, divide by a different process called binary fission.[12]
^"Cell division and growth". britannica.com. ENCYCLOPÆDIA BRITANNICA. Archived from the original on 2018-10-28. Retrieved 2018-11-04.
^Carter JS (2014-01-14). "Mitosis". biology.clc.uc.edu. Archived from the original on 2012-10-27. Retrieved 2019-11-12.
^"Mitosis - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2020-11-24.
^"Cell Division: Stages of Mitosis | Learn Science at Scitable". www.nature.com. Archived from the original on 2015-11-14. Retrieved 2015-11-16.
^Cite error: The named reference Maton1997 was invoked but never defined (see the help page).
^Sandoz PA (December 2019). "Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux". PLOS Biology. 17 (12): e3000553. doi:10.1371/journal.pbio.3000553. PMC 6922317. PMID 31856161.
^Kalatova B, Jesenska R, Hlinka D, Dudas M (January 2015). "Tripolar mitosis in human cells and embryos: occurrence, pathophysiology and medical implications". Acta Histochemica. 117 (1): 111–25. doi:10.1016/j.acthis.2014.11.009. PMID 25554607.
^Kops GJ, Weaver BA, Cleveland DW (October 2005). "On the road to cancer: aneuploidy and the mitotic checkpoint". Nature Reviews. Cancer. 5 (10): 773–85. doi:10.1038/nrc1714. PMID 16195750. S2CID 2515388.
^Cite error: The named reference Raikov1994 was invoked but never defined (see the help page).
^Cite error: The named reference DeSouza2007 was invoked but never defined (see the help page).
^Boettcher B, Barral Y (2013). "The cell biology of open and closed mitosis". Nucleus. 4 (3): 160–5. doi:10.4161/nucl.24676. PMC 3720745. PMID 23644379.
^Patil, C. s. Cell Biology. APH Publishing. ISBN 978-81-313-0416-7.
Mitosis (/maɪˈtoʊsɪs/) is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis is an equational...
chromatids is released and they segregate from one another, as during mitosis. In some cases, all four of the meiotic products form gametes such as sperm...
there are two distinct types of cell division: a vegetative division (mitosis), producing daughter cells genetically identical to the parent cell, and...
interphase, and mitosis in the M phase that also includes cytokinesis. During interphase, the cell grows, accumulating nutrients needed for mitosis, and replicates...
for mitosis, and conducts other "normal" cell functions. A common misconception is that interphase is the first stage of mitosis, but since mitosis is...
φάσις (phásis) 'appearance') is the first stage of cell division in both mitosis and meiosis. Beginning after interphase, DNA has already been replicated...
diploid gametocytes into various gametes, or by mitosis. For example, plants produce gametes through mitosis in gametophytes. The gametophytes grow from haploid...
chromosomes or sister chromatids to separate properly during cell division (mitosis/meiosis). There are three forms of nondisjunction: failure of a pair of...
the third subphase of interphase in the cell cycle directly preceding mitosis. It follows the successful completion of S phase, during which the cell’s...
Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered...
chromatids are separated from each other into two different cells during mitosis or during the second division of meiosis. Compare sister chromatids to...
and φάσις (phásis) 'appearance') is the final stage in both meiosis and mitosis in a eukaryotic cell. During telophase, the effects of prophase and prometaphase...
by prolonged activation of the spindle assembly checkpoint, errors in mitosis, or DNA damage and operates to prevent genomic instability. It is a mechanism...
called mitosis from the Greek word for thread. However, he did not see the splitting into identical halves, the daughter chromatids. He studied mitosis both...
"sporic". The cycles differ in when mitosis (growth) occurs. Zygotic meiosis and gametic meiosis have one mitotic stage: mitosis occurs during the n phase in...
by mitosis. In animals there is no corresponding multicellular haploid phase. The sperm of plants that reproduce using spores are formed by mitosis in...
which the genome is replicated during S-phase but there is no subsequent mitosis (M-phase) or cell division (cytokinesis). These large endoreplicating cells...
cell cycle. Geminin levels drop at the metaphase-anaphase transition of mitosis when it is degraded by the anaphase-promoting complex. During S phase,...
reticulum show up during mitosis. In addition to the breakdown of the nuclear membrane during the prometaphase stage of mitosis, the nuclear membrane also...
organism's mother; the other is inherited from the organism's father. After mitosis occurs within the daughter cells, they have the correct number of genes...
sometimes called protists. Eukaryotes can reproduce both asexually through mitosis and sexually through meiosis and gamete fusion (fertilization). Eukaryotes...
macromolecular assemblies. They are also involved in cell division (by mitosis and meiosis) and are the main constituents of mitotic spindles, which are...
Gymnosperm plant. Mitosis and meiosis are types of cell division. Mitosis occurs in somatic cells, while meiosis occurs in gametes. Mitosis The resultant...
division, or enhances the rate of division (mitosis). Mitogenesis is the induction (triggering) of mitosis, typically via a mitogen. The mechanism of action...
Firefight books. In it, the Epic Mitosis does not believe that David was the one to bring down Steelheart. Mitosis's ability is to split into multiple...
come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair...
heterochromatin, which is sometimes expressed. In the early stages of mitosis or meiosis (cell division), the chromatin double helix becomes more and...
a dyad. Once sister chromatids have separated (during the anaphase of mitosis or the anaphase II of meiosis during sexual reproduction), they are again...
(/ˌsaɪtoʊkɪˈniːsɪs/) is the part of the cell division process and part of mitosis during which the cytoplasm of a single eukaryotic cell divides into two...
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