A cell that has been treated with taxol and had a catastrophic mitosis. The cell has become multinucleated after an unsuccessful mitosis.
Mitotic catastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular death that occurs following improper cell cycle progression or entrance.[1][2] Mitotic catastrophe can be induced by prolonged activation of the spindle assembly checkpoint, errors in mitosis, or DNA damage and operates to prevent genomic instability.[3] It is a mechanism that is being researched as a potential therapeutic target in cancers, and numerous approved therapeutics induce mitotic catastrophe.[4]
^Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Annicchiarico-Petruzzelli, Margherita; Antonov, Alexey V.; Arama, Eli; Baehrecke, Eric H.; Barlev, Nickolai A. (March 2018). "Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018". Cell Death & Differentiation. 25 (3): 486–541. doi:10.1038/s41418-017-0012-4. ISSN 1476-5403. PMC 5864239. PMID 29362479.
^Denisenko, Tatiana V.; Sorokina, Irina V.; Gogvadze, Vladimir; Zhivotovsky, Boris (January 2016). "Mitotic catastrophe and cancer drug resistance: A link that must to be broken". Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 24: 1–12. doi:10.1016/j.drup.2015.11.002. ISSN 1532-2084. PMID 26830311.
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Mitoticcatastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular...
embryos that fail to implant. Other errors during mitosis can induce mitoticcatastrophe, apoptosis (programmed cell death) or cause mutations. Certain types...
Malthusian catastrophe, prediction of a forced return to subsistence-level conditions once population growth has outpaced agricultural production Mitotic catastrophe...
cytoplasm vacuolization, and swelling of the nucleus and cytoplasm. Mitoticcatastrophe is an oncosuppressive mechanism that can lead to cell death that...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
chromosomal instability and translocation, the cell may undergo mitoticcatastrophe. Usually, this will make the cell initiate apoptosis leading to its...
separate sister chromatids between daughter cells. It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
along the yeast lineage. Cellular model Eukaryotic DNA replication Mitoticcatastrophe Origin recognition complex Retinoblastoma protein Synchronous culture...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
taxanes prevent their disassembly. By doing so, they can induce mitoticcatastrophe in the cancer cells. Following this, cell cycle arrest occurs, which...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
Cyclin-dependent kinase Labile cells, cells that constantly divide Mitoticcatastrophe Martin EA, Hine R (2020). A dictionary of biology (6th ed.). Oxford:...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
cell death Ischemic cell death Pyknosis Karyorrhexis Karyolysis Mitoticcatastrophe Suicide gene Abortion Accidental death Autopsy Brain death Brainstem...
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