double-strand break repair via break-induced replication
pre-replicative complex assembly involved in nuclear cell cycle DNA replication
DNA strand elongation involved in DNA replication
mitotic DNA replication initiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4173
17217
Ensembl
n/a
ENSMUSG00000022673
UniProt
P33991
P49717
RefSeq (mRNA)
NM_005914 NM_182746
NM_008565
RefSeq (protein)
NP_005905 NP_877423
NP_032591
Location (UCSC)
n/a
Chr 16: 15.44 – 15.46 Mb
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.[4]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022673 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Musahl C, Schulte D, Burkhart R, Knippers R (August 1995). "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins". Eur J Biochem. 230 (3): 1096–101. doi:10.1111/j.1432-1033.1995.tb20660.x. PMID 7601140.
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene. The protein encoded by this gene is one of the highly conserved...
Hanaoka F (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9...
Route Terminal A Major streets Terminal B History MCM4 Morristown, or Morris Township Honeywell (to AM, from PM) Routes 510 and 513, via Chester Chester...
DNA-bound MCM-DH, contacting Mcm2 of one hexamer and Mcm4/6 of the opposite hexamer. Mcm2, Mcm4 and Mcm6 are all substrates of phosphorylation by DDK...
other DNA replication-related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex...
mutants were mcm1, mcm2, mcm3, mcm5 and mcm10. Later on, others identified Mcm4, Mcm6 and Mcm7 in yeasts and other eukaryotes based on homology to Mcm2p...
R. J., Hartford, S. A., Tye, B. K. & Schimenti, J. C. A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat Genet...
the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and...
DNA dependent polymerase alpha (Pol α) has been shown to interact with MCM4 and GINS1, Retinoblastoma protein, PARP1 and RBMS1. DNA Polymerase DNA polymerase...
initiation and progression of DNA synthesis. Phosphorylation of CDC6 and MCM4 by the cyclin A2-CDK2 complex prevents re-replication of DNA during the cell...