double-strand break repair via break-induced replication
pre-replicative complex assembly involved in nuclear cell cycle DNA replication
mitotic DNA replication initiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4171
17216
Ensembl
ENSG00000073111
ENSMUSG00000002870
UniProt
P49736
P97310
RefSeq (mRNA)
NM_004526
NM_008564
RefSeq (protein)
NP_004517
NP_032590
Location (UCSC)
Chr 3: 127.6 – 127.62 Mb
Chr 6: 88.86 – 88.88 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000073111 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002870 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun. 177 (1): 395–400. doi:10.1016/0006-291X(91)91996-P. PMID 1710453.
^Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet. 65 (4): 276–7. doi:10.1159/000133647. PMID 8258304.
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene. The protein encoded by this gene is one of the highly conserved...
Cdc6, and Cdt1 together are required for the stable association of the Mcm2-7 complex with replicative origins during the G1 phase of the cell cycle...
for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. As a critical protein for cell division, MCM...
pre-replication complex (pre-RC), which includes Cdc6, Tah11 (a.k.a. Cdt1), and the Mcm2-Mcm7 complex. Pre-RC assembly during G1 is required for replication licensing...
Ledgewood Mall Morristown station Route 10 Route 53 Route 202 Formerly parts of MCM2. 880 Rockaway Townsquare Mall Morristown station West Main Street Route 46...
the minichromosome maintenance 2-7 (Mcm2-7) complex onto DNA. Like the archaeal replicative helicase core, Mcm2-7 is loaded as a head-to-head double...
maintenance (MCM) genes in yeast in 1984. She specifically identified the MCM2, MCM3, MCM5 and MCM10 genes in yeast. Her findings together with the identification...
genome replication. The MCM complex consisting of MCM6 (this protein) and MCM2, 4 and 7 possesses DNA helicase activity, and may act as a DNA unwinding...
is encoded by the MCM10 gene. It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication. The protein...
the origin recognition complex (ORC), Cdt1 and the MCM complex (containing MCM2-7p). CDC6 assembles after ORC in an ATP dependent manner and is required...
DNA and separates the strands ahead of DNA synthesis. In eukaryotes, the Mcm2-7 complex acts as a helicase, though which subunits are required for helicase...
subunit of PKA. AKAP8 has been demonstrated to interact with: Cyclin D3 DDX5, MCM2, MYCBP, and PRKAR2A. GRCh38: Ensembl release 89: ENSG00000105127 – Ensembl...
EA, Su TV, Liu Y (October 2009). "MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication". The EMBO Journal. 28 (19): 3005–3014...
regulate the localization of Mcm2-7 is that inactivation of CDKs in nocodazole arrested cells induced accumulation of Mcm2-7 in the nucleus. Cdt1 is also...
disease, affected neurons show signs of DNA replication such as phosphorylated Mcm2 and cell cycle regulators cyclin D, Cdk4, phosphorylated Rb, E2F1, and cyclin...
to the forming pre-RC, followed by minichromosome maintenance complexes (MCM2-7). The activity of CDT1 during the cell cycle is tightly regulated during...
until June 19, 2006, multiplayer gameplay through the MSN Gaming Network. In MCM2, there are six types of racing: Stunts, Enduro, Baja, Supercross and Nationals...
Global Information
