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Midodrine information


Midodrine
Clinical data
Trade namesAmatine, Proamatine, Gutron, others
Other names2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxy-ethyl]-acetamide
AHFS/Drugs.comMonograph
MedlinePlusa602023
License data
  • US DailyMed: Midodrine
Pregnancy
category
  • AU: C
Routes of
administration
By mouth
ATC code
  • C01CA17 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only[1]
Identifiers
IUPAC name
  • (RS)- N-[2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl]glycinamide
CAS Number
  • 42794-76-3 checkY
PubChem CID
  • 4195
IUPHAR/BPS
  • 7240
DrugBank
  • DB00211 checkY
ChemSpider
  • 4050 checkY
UNII
  • 6YE7PBM15H
KEGG
  • D08220 checkY
ChEBI
  • CHEBI:6933 checkY
ChEMBL
  • ChEMBL1076 ☒N
CompTox Dashboard (EPA)
  • DTXSID0023321 Edit this at Wikidata
ECHA InfoCard100.151.349 100.050.842, 100.151.349 Edit this at Wikidata
Chemical and physical data
FormulaC12H18N2O4
Molar mass254.286 g·mol−1
3D model (JSmol)
  • Interactive image
ChiralityRacemic mixture
SMILES
  • O=C(NCC(O)c1cc(OC)ccc1OC)CN
InChI
  • InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16) checkY
  • Key:PTKSEFOSCHHMPD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Midodrine is a vasopressor/antihypotensive agent (it raises the blood pressure). Midodrine was approved in the United States by the Food and Drug Administration (FDA) in 1996 for the treatment of dysautonomia and orthostatic hypotension. In August 2010, the FDA proposed withdrawing this approval because the manufacturer, Shire plc, failed to complete required studies after the medicine reached the market.[2][3] In September 2010, the FDA reversed its decision to remove midodrine from the market and allowed it to remain available to patients while Shire plc collected further data regarding the efficacy and safety of the drug.[4] Shire announced on September 22, 2011, that it was withdrawing completely from supplying midodrine and leaving it to several generics to supply the drug.[5]

  1. ^ "Proamatine- midodrine hydrochloride tablet". DailyMed. Retrieved 14 August 2021.
  2. ^ U.S. proposes withdrawal of Shire hypotension drug, 16 August 2010.
  3. ^ O'Riordan M. "FDA recommends withdrawal of midodrine". Food and Drug Administration. FDA proposes withdrawal of low blood pressure drug [press release]. August 16, 2010. TheHeart.org. Retrieved 1 April 2011.
  4. ^ Midodrine (ProAmatine, generic) Proposed Market Withdrawal – Update 10 September 2010.
  5. ^ Shire plc. "Shire Provides Update on ProAmatine® (midodrine HCl)". www.prnewswire.com.

and 28 Related for: Midodrine information

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Midodrine

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Midodrine is a vasopressor/antihypotensive agent (it raises the blood pressure). Midodrine was approved in the United States by the Food and Drug Administration...

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Postural orthostatic tachycardia syndrome

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medications. Medications used may include beta blockers, pyridostigmine, midodrine or fludrocortisone. More than 50% of patients whose condition was triggered...

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Reflex syncope

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this is insufficient for treating vasovagal syncope, medications such as midodrine or fludrocortisone may be tried. Occasionally, a cardiac pacemaker may...

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Droxidopa

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droxidopa and midodrine have found that midodrine was more likely to cause supine hypertension than droxidopa in patients with NOH. Midodrine was also found...

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Methoxamine

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longer marketed.[why?] Sertraline Phenylephrine Synephrine Phentolamine Midodrine Pazdernik TL, Kerecsen L (2007) [2003]. "5". In Goljan EF (ed.). Pharmacology...

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Orthostatic hypotension

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wearing compression stockings, and sometimes medication (fludrocortisone, midodrine, or others). Salt loading (dramatic increases in salt intake) must be...

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Supine hypertension

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autonomic nervous system or due to side effects of medications such as midodrine and droxidopa. Naschitz, J E; Slobodin, G; Elias, N; Rosner, I (April...

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Antihypotensive agent

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Noradrenaline Phenylephrine Dobutamine Dopamine Dopexamine Ephedrine Midodrine Amezinium Metaraminol Vasopressin Angiotensinamide S-alkylisothiouronium...

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Hypotension

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include Fludrocortisone, Erythropoietin, and Sympathomimetics such as Midodrine and Noradrenaline and precursor (L-DOPS). Fludrocortisone is the first-line...

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Octreotide

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malignant bowel obstruction. Octreotide may be used in conjunction with midodrine to partially reverse peripheral vasodilation in the hepatorenal syndrome...

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Rilmenidine

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Hepatorenal syndrome

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of albumin in conjunction with other medical or procedural treatment. Midodrine is an alpha-agonist and octreotide is an analogue of somatostatin, a hormone...

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LSD

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Chylothorax

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medication to prevent chyle formation including somatostatin/octreotide, midodrine and sirolimus, pleurodesis, and surgical treatment including ligation...

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Adrenergic agonist

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α selective & β selective. α1 selective: phenylephrine, methoxamine, midodrine, oxymetazoline. α2 selective: α-methyldopa, clonidine, brimonidine, dexmedetomidine...

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Beta blocker

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Orthostatic intolerance

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that improve vasoconstriction: Stimulants: (e.g., Ritalin or Dexedrine) Midodrine (ProAmatine) Ephedrine and pseudoephedrine (Sudafed) Theophylline (low-dose)...

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Aripiprazole

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Promethazine

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Olanzapine

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Chlorpromazine

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Salbutamol

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Phenylephrine

Last Update:

L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Mirabegron

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Tizanidine

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Trazodone

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Mirtazapine

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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Cyclobenzaprine

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L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine Oxymetazoline Phenylephrine Phenylpropanolamine...

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