Droxidopa information

Droxidopa
Clinical data
Trade names	Northera
Other names	β,3-Dihydroxytyrosine
AHFS/Drugs.com	Monograph
MedlinePlus	a614025
License data	US DailyMed: Droxidopa;
Routes of; administration	By mouth
ATC code	C01CA27 (WHO) ;
Legal status
Legal status	US: WARNINGRx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	90%
Metabolism	Liver
Elimination half-life	1.5 hours
Excretion	Kidney
Identifiers
	IUPAC name (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid;
CAS Number	23651-95-8 ;
PubChem CID	92974;
DrugBank	DB06262;
ChemSpider	83927;
UNII	J7A92W69L7;
KEGG	D01277;
ChEBI	CHEBI:31524;
ChEMBL	ChEMBL2103827;
CompTox Dashboard (EPA)	DTXSID6046422 ;
ECHA InfoCard	100.215.254
Chemical and physical data
Formula	C9H11NO5
Molar mass	213.189 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1;
	InChI InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1; Key:QXWYKJLNLSIPIN-JGVFFNPUSA-Na;
	(verify)

Droxidopa (INN; trade name Northera; also known as L-DOPS, L-threo-dihydroxyphenylserine, L-threo-DOPS and SM-5688) is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitter norepinephrine (noradrenaline).^[2] Unlike norepinephrine, droxidopa is capable of crossing the protective blood–brain barrier (BBB).^[2]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ ^a ^b Goldstein DS (2006). "L-Dihydroxyphenylserine (_L-DOPS): a norepinephrine prodrug". Cardiovascular Drug Reviews. 24 (3–4): 189–203. doi:10.1111/j.1527-3466.2006.00189.x. PMID 17214596.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[Goldstein-2] Goldstein DS (2006). "L-Dihydroxyphenylserine (_L-DOPS): a norepinephrine prodrug". Cardiovascular Drug Reviews. 24 (3–4): 189–203. doi:10.1111/j.1527-3466.2006.00189.x. PMID 17214596.

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