Mepivacaine/mɛˈpɪvəkeɪn/ is a local anesthetic[1] of the amide type. Mepivacaine has a reasonably rapid onset (less rapid than that of procaine) and medium duration of action (longer than that of procaine)[2][3] and is marketed under various trade names including Carbocaine and Polocaine.
Mepivacaine became available in the United States in the 1960s.
Mepivacaine is used in any infiltration and local anesthesia.
It is supplied as the hydrochloride salt of the racemate,[4] which consists of R(-)-mepivacaine and S(+)-mepivacaine in equal proportions. These two enantiomers have markedly different pharmacokinetic properties.[4]
Mepivacaine was originally synthesized in Sweden at the laboratory of Bofors Nobelkrut in 1956.[5]
^Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Medicina oral, patología oral y cirugía bucal. 12 (1): E60–4. PMID 17195831.
^ abBurm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesthesia & Analgesia. 84 (1): 85–9. doi:10.1097/00000539-199701000-00016. PMID 8989005. S2CID 22363370.
^Castrén, J.A. (1963). "A clinical evaluation of mepivacaine (Carbocain) in ocular surgery". Acta Ophthalmologica. 41 (3): 262–9. doi:10.1111/j.1755-3768.1963.tb02436.x. PMID 14047466. S2CID 32119846.
Mepivacaine /mɛˈpɪvəkeɪn/ is a local anesthetic of the amide type. Mepivacaine has a reasonably rapid onset (less rapid than that of procaine) and medium...
States, (usually in a pre-mixed solution with local anesthetics, such as mepivacaine). Corbadrine is also a metabolite of the antihypertensive drug methyldopa...
procaine, tetracaine, and chloroprocaine. The amides include lidocaine, mepivacaine, prilocaine, bupivacaine, ropivacaine, and levobupivacaine. Chloroprocaine...
hypertension or local vasoconstriction, with the exception of Ropivacaine and Mepivacaine that do produce weak vasoconstriction. Unlike other forms of anesthesia...
such as Sufenta and Sufentil. Sufentanil with and without lidocaine or mepivacaine is available as a transdermal patch similar to Duragesic in Europe under...
Unlike lidocaine, the terminal amino portion of bupivacaine (as well as mepivacaine, ropivacaine, and levobupivacaine) is contained within a piperidine ring;...
as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, thus is often coadministered...
bupivacaine (a long-acting anesthetic), prilocaine (also called Citanest), and mepivacaine (also called Carbocaine or Polocaine). Different types of local anaesthetic...
neurological symptoms. Low quality evidence suggests that 2‐chloroprocaine and mepivacaine when used for spinal anesthetic have a similar risk of the person developing...
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