Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease sensation in a specific small area.[5] In nerve blocks, it is injected around a nerve that supplies the area, or into the spinal canal's epidural space.[5] It is available mixed with a small amount of epinephrine to increase the duration of its action.[5] It typically begins working within 15 minutes and lasts for 2 to 8 hours.[5][6]
Possible side effects include sleepiness, muscle twitching, ringing in the ears, changes in vision, low blood pressure, and an irregular heart rate.[5] Concerns exist that injecting it into a joint can cause problems with the cartilage.[5] Concentrated bupivacaine is not recommended for epidural freezing.[5] Epidural freezing may also increase the length of labor.[5] It is a local anaesthetic of the amide group.[5]
Bupivacaine was discovered in 1957.[7] It is on the World Health Organization's List of Essential Medicines.[8] Bupivacaine is available as a generic medication.[5][9] An implantable formulation of bupivacaine (Xaracoll) was approved for medical use in the United States in August 2020.[10][11][12]
^"Bupivacaine Use During Pregnancy". Drugs.com. 13 April 2020. Retrieved 21 September 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Marcaine- bupivacaine hydrochloride injection, solution Marcaine with epinephrine- bupivacaine hydrochloride and epinephrine bitartrate injection, solution". DailyMed. Retrieved 13 February 2021.
^ abcdefghijklm"Bupivacaine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 30 June 2015. Retrieved 1 August 2015.
^ abWhimster DS (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 194. ISBN 9780521433792. Archived from the original on 5 October 2015.
^Egan TD (2013). Pharmacology and physiology for anesthesia : foundations and clinical application. Philadelphia, PA: Elsevier/Saunders. p. 291. ISBN 9781437716795. Archived from the original on 12 May 2016.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 22. ISBN 9781284057560.
^"Xaracoll: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 2 September 2020.
^Cite error: The named reference FDA Xaracoll approval letter was invoked but never defined (see the help page).
^Cite error: The named reference Innocoll PR was invoked but never defined (see the help page).
Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease sensation in a specific small area. In nerve blocks...
into the nerve cells. Levobupivacaine is the S-enantiomer of racemic bupivacaine and therefore similar in pharmacological effects. The drug typically...
AstraZeneca under the brand name Naropin. Ropivacaine was developed after bupivacaine was noted to be associated with cardiac arrest, particularly in pregnant...
Potency Lidocaine Prilocaine High Duration and High Potency Tetracaine Bupivacaine Cinchocaine Ropivacaine Local anesthetics may be used to prevent and/or...
medical source] and allowed to diffuse posteriorly, whereas others (e.g., bupivacaine) must be distributed throughout the body of the muscle,[unreliable medical...
spinal must be injected below L2 to avoid piercing the spinal cord. Bupivacaine (Marcaine) is the local anaesthetic most commonly used, although lidocaine...
repeatedly. It is also under investigation whether the injection of bupivacaine into extraocular muscles is of possible therapeutic use for treating...
stimulants such as cocaine; or an incorrectly administered drug such as bupivacaine. One of the ways to detect cardiotoxicity at early stages when there...
bupivacaine (Marcaine) is often used. A mixture of 1 part 2% lidocaine with 3 parts 0.5% bupivacaine provides 0.5% lidocaine and 0.375% bupivacaine....
fascial plane blocks that may be provided instead of an epidural. If bupivacaine, a medication commonly administered via epidural, is inadvertently administered...
infiltration, block, and surface anaesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for spinal and epidural anaesthesias;...
following compounds are known to be pseudo-uncouplers: Azide Biguanides Bupivacaine Calcimycin (A23187) Dodecyltriphenylphosphonium (C12TPP) Lasalocid (X537A)...
cardiotoxicity from intravenous overdose of local anaesthetic drugs such as bupivacaine. They have been effective in people unresponsive to the usual resuscitation...
from an injection of bupivacaine or had a history of difficulty getting numb at the dentist. Skin testing with lidocaine, bupivacaine, and mepivacaine was...
Intra-articular infusions of certain local anesthetic agents such as bupivacaine, lidocaine, ropivacaine and levobupivacaine can also lead to this effect...
rapid onset of analgesia in labour. It further recommends the use of bupivacaine and fentanyl to establish the block. Combined spinal-epidural anaesthesia...
tranexamic acid, infusion of vitamin C, infiltration of a mixture of bupivacaine and epinephrine into the uterine muscles, or the use of a fibrin sealant...
One patient has been treated with "paravertebral nerve blocks, with bupivacaine and methylprednisolone acetate injected into the T3–T4 and T5–T6 intervertebral...
the patient feel no pain bexagliflozin - oral antidiabetic medication bupivacaine – local anesthetic primarily utilized pre- and post-operatively buprenorphine...
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