This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Matrix metalloproteinase inhibitor" – news · newspapers · books · scholar · JSTOR(December 2013) (Learn how and when to remove this message)
A matrix metalloproteinase inhibitor (INN stem –mastat[1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs.[2] Examples include:
Batimastat
Cipemastat
Ilomastat
Marimastat
Prinomastat
Tanomastat
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria.[3]
^"The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). World Health Organization. Retrieved 5 November 2016.
^Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations". Science. 295 (5564): 2387–2392. Bibcode:2002Sci...295.2387C. doi:10.1126/science.1067100. ISSN 0036-8075. PMID 11923519. S2CID 19944201.
^Noel Vinay Thomas; Se Kwon Kim (2010). "Metalloproteinase Inhibitors Stts and Scope from Marine Organisms". Biochemistry Research International. 2010: 845975. doi:10.1155/2010/845975. PMC 3004377. PMID 21197102.
and 28 Related for: Matrix metalloproteinase inhibitor information
A matrixmetalloproteinaseinhibitor (INN stem –mastat) inhibitsmatrixmetalloproteinases. Because they inhibit cell migration, they have antiangiogenic...
Matrixmetalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing...
Metalloprotease inhibitors are cellular inhibitors of the Matrixmetalloproteinases (MMPs). MMPs belong to a family of zinc-dependent neutral endopeptidases...
Stromelysin-1 also known as matrixmetalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster...
in humans is encoded by the MMP13 gene. It is a member of the matrixmetalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form...
Matrixmetalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded...
Matrixmetalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene. Proteins of the matrixmetalloproteinase (MMP) family are involved...
Tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous protease inhibitors to the matrixmetalloproteinases. There are four TIMPs; TIMP1...
metalloendopeptidases include ADAM proteins and matrixmetalloproteinases, and M16 metalloproteinases such as Insulin Degrading Enzyme and Presequence...
TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein with a molecular weight of 28 kDa....
belongs to the family of drugs called angiogenesis inhibitors. It acts as a matrixmetalloproteinaseinhibitor (MMPI) by mimicking natural MMPI peptides. Dan...
(codenamed GM6001, proprietary name Galardin®) is a broad-spectrum matrixmetalloproteinaseinhibitor. This chemotherapy agent is considered to have application...
72 kDa type IV collagenase also known as matrixmetalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The...
Matrilysin also known as matrixmetalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme in humans that is encoded...
developed by British Biotech. It acted as a broad-spectrum matrixmetalloproteinaseinhibitor. Marimastat performed poorly in clinical trials, and development...
Interstitial collagenase, also known as fibroblast collagenase and matrixmetalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1 gene...
are natural inhibitors of the matrixmetalloproteinases (MMP), a group of peptidases involved in degradation of the extracellular matrix. In addition...
An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and...
Matrixmetalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes...
and by the tentative trade name Trocade) is a selective inhibitor of matrixmetalloproteinase-1 that has been investigated as an anti-arthritis agent...
Prinomastat (code name AG-3340) is a matrixmetalloproteinase (MMP) inhibitor with specific selectivity for MMPs 2, 3, 9, 13, and 14. Investigations have...
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more...
Plant matrixmetalloproteinases are metalloproteins and zinc enzymes found in plants. Matrixmetalloproteinases (MMPs) are zinc endopeptidases, commonly...
C-glycoside and a depside. In terms of mechanism of action it is a matrixmetalloproteinaseinhibitor. Species described in Emericella were identified as teleomorphs...
Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK...
Neutrophil collagenase, also known as matrixmetalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in...
Global Information