Interstitial collagenase, also known as fibroblast collagenase and matrix metalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1 gene.[1][2][3][4] The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[2] MMP-1 was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA.[5][6] MMP-1 has an estimated molecular mass of 54 kDa.[7]
^"UniProt". www.uniprot.org. Retrieved 17 July 2022.
^ abEntrezGene 4312
^Brinckerhoff CE, Ruby PL, Austin SD, Fini ME, White HD (February 1987). "Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA". J. Clin. Invest. 79 (2): 542–6. doi:10.1172/JCI112845. PMC 424122. PMID 3027129.
^Pendás AM, Santamaría I, Alvarez MV, Pritchard M, López-Otín C (October 1996). "Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3". Genomics. 37 (2): 266–8. doi:10.1006/geno.1996.0557. PMID 8921407.
^Gross J, Lapiere CM (June 1962). "Collagenolytic activity in amphibian tissues: a tissue culture assay". Proc. Natl. Acad. Sci. U.S.A. 48 (6): 1014–22. Bibcode:1962PNAS...48.1014G. doi:10.1073/pnas.48.6.1014. PMC 220898. PMID 13902219.
^Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ (May 1986). "Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein". J. Biol. Chem. 261 (14): 6600–5. doi:10.1016/S0021-9258(19)84605-7. PMID 3009463.
Interstitialcollagenase, also known as fibroblast collagenase and matrix metalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1...
particular, interstitial may refer to: Interstitial cell, any cell that lies between other cells Interstitial cell tumor Interstitialcollagenase, enzyme...
Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such...
tail in a collagen matrix plate). Therefore, the enzyme was named interstitialcollagenase (MMP-1). Later, it was purified from human skin (1968), and was...
chemical reaction Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitialcollagenase, this enzyme cleaves type...
four in 10,000 people. Mutations in MMP1 gene that encodes for interstitialcollagenase are associated with COPD. The COPDGene study is an ongoing longitudinal...
Type V collagen has shown that it is resistant to digestion by interstitialcollagenases. Denatured collagen V on the other hand, can be degraded by gelatinases...
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene....
and V is weak This enzyme belongs to the peptidase family M10 (interstitialcollagenase family). Breathnach R, Matrisian LM, Gesnel MC, Staub A, Leroy...
predominates over matrix metalloproteinase-8 as the functional interstitialcollagenase in mouse atheromata". Arteriosclerosis, Thrombosis, and Vascular...
Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes...
MMP-1 expression through activation of the MAPK pathway. MMP-1 (interstitialcollagenase) cleaves collagen type I, II, III, VII and X. Therefore, tenascin...
an inducer of matrix metalloproteinase synthesis, also binds interstitialcollagenase to the tumor cell surface". Cancer Research. 60 (4): 888–891. PMID 10706100...
inflammation. They migrate through the blood vessels and then through interstitial space, following chemical signals such as interleukin-8 (IL-8), C5a,...
metalloproteinases such as stromelysin, which degrade cartilage matrix proteins; collagenases such as cathepsin B1; and hyaluronidase. PSGAG inhibits the synthesis...
Synovial fluid is made of hyaluronic acid and lubricin, proteinases, and collagenases. Synovial fluid exhibits non-Newtonian flow characteristics; the viscosity...
break down extracellular matrix components (matrix metalloproteinases, collagenases). While early stage HFrEF is associated with a significant disruption...
Many bacteria and viruses secrete virulence factors, such as the enzyme collagenase, which destroys collagen or interferes with its production. A single...
enzyme-substrate interactions, MMPs in the first group, called collagenases, have interstitial collagens. The second group, called gelatinases, degrade denatured...
(Proteinase 3) Lysozyme Bactericidal permeability-increasing protein Collagenase Specific granules (2°) see also platelet alpha-granule, dense granule...
for cell sorting. The stress conditions included; long incubation with collagenase, low temperature, serum deprivation, and severe hypoxia for 16 hours...
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