An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet.
While angiogenesis is a critical part of wound healing and other favorable processes, certain types of angiogenesis are associated with the growth of malignant tumors. Thus angiogenesis inhibitors have been closely studied for possible cancer treatment. Angiogenesis inhibitors were once thought to have potential as a "silver bullet" treatment applicable to many types of cancer, but the limitations of anti-angiogenic therapy have been shown in practice.[1] Currently, angiogenesis inhibitors are recognized for their improvement of cancer immunotherapy[2][3] by overcoming endothelial cell anergy. Angiogenesis inhibitors are also used to effectively treat macular degeneration in the eye, and other diseases that involve a proliferation of blood vessels.[4][5][6]
^Fukumura, D., et al., Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol, 2018. 15(5): p. 325-340. doi: 10.1038/nrclinonc.2018.29
^Huinen, Z., et al., Anti-angiogenic agents - overcoming tumor endothelial cell anergy and improving immunotherapy outcomes. Nat. Rev. Clin. Oncol., 2021. 18(8): p. 527-540. doi: 10.1038/s41571-021-00496-y
^Dudley, A.C. & Griffioen, A.W., Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis, 2023. doi: 10.1007/s10456-023-09876-7
^Cancer.com [homepage on the Internet]. National Cancer Institute at the National Institutes of Health; 2011 [cited 18 March 2014]. Available from: "Angiogenesis Inhibitors". Archived from the original on 2015-02-08. Retrieved 2022-05-09.
^Ng EW, Adamis AP (June 2005). "Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration". Canadian Journal of Ophthalmology. 40 (3): 352–68. doi:10.1016/S0008-4182(05)80078-X. PMID 15947805.
and 19 Related for: Angiogenesis inhibitor information
An angiogenesisinhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesisinhibitors are endogenous and...
Angiogenesis continues the growth of the vasculature mainly by processes of sprouting and splitting, but processes such as coalescent angiogenesis, vessel...
angiogenesis, the process by which a tumor attracts blood vessels to nourish itself and sustain its existence. He founded the field of angiogenesis research...
angiostatin and thrombospondin. Endostatin is a broad-spectrum angiogenesisinhibitor and may interfere with the pro-angiogenic action of growth factors...
involved in angiogenesis. This article focuses on the important and diverse roles that these proteases play in the regulation of angiogenesis. Matrix metalloproteinases...
antibody that functions as an angiogenesisinhibitor. It works by slowing the growth of new blood vessels by inhibiting vascular endothelial growth factor...
series of separate therapies such as chemotherapy before surgery. Angiogenesisinhibitors are sometimes used to enhance the effects of immunotherapies. The...
class of compounds known as isoflavones. It is described as an angiogenesisinhibitor and a phytoestrogen. It was first isolated in 1899 from the dyer's...
in several animal species, including humans. It is an endogenous angiogenesisinhibitor (i.e., it blocks the growth of new blood vessels). Clinical trials...
This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesisinhibitor. An additional isoform encoded...
codenamed PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibitsangiogenesis. It is being studied as a possible treatment for several...
molecular basis of a subtype of hereditary angioedema with normal C1-inhibitor; the mutation creates a new lysine-binding site within kringle 3 and alters...
tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesisinhibitors. Exogenous matrix metalloproteinase inhibitors were developed...
involved in angiogenesis. Inhibition of TNF-α is not the mechanism of thalidomide's inhibition of angiogenesis since numerous other TNF-α inhibitors do not...
would cause the down-regulation of an angiogenesisinhibitor, thrombospondin-1, and the up-regulation of an angiogenesis activator which is platelet-derived...
findings helped lead to development of the first clinically available angiogenesisinhibitor, bevacizumab (Avastin), which prevents the growth of new blood vessels...
treatment was ongoing. Bishop detailed undergoing therapy using the angiogenesisinhibiting drug, Avastin. Bishop announced on the same podcast that, because...
brain-specific angiogenesisinhibitor receptors amongst others. They are otherwise known as Adhesion G protein-coupled receptors. Brain-specific angiogenesis inhibitor...
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