Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer.[2][3] In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks.[2] It is taken by mouth.[2]
Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches.[2][3] There is also concern that it increases the risk of later cancers.[2] Use during pregnancy is typically harmful to the fetus.[2] Hydroxycarbamide is in the antineoplastic family of medications. It is believed to work by blocking the making of DNA.[2]
Hydroxycarbamide was approved for medical use in the United States in 1967.[2] It is on the World Health Organization's List of Essential Medicines.[4] Hydroxycarbamide is available as a generic medication.[2]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ abcdefghi"Hydroxyurea". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
^ ab"Hydrea 500 mg Hard Capsules – Summary of Product Characteristics (SPC) – (eMC)". www.medicines.org.uk. Archived from the original on 20 December 2016. Retrieved 14 December 2016.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia...
treated with aspirin, whereas those at high risk are treated with hydroxycarbamide, interferon-α or anagrelide). Currently unapproved but in late-stage...
transfusions. Dexamethasone, alpha-interferon and hydroxyurea (also known as hydroxycarbamide) may play a role. Lenalidomide and thalidomide may be used in its treatment...
medication. Other measures may include blood transfusion and the medication hydroxycarbamide (hydroxyurea). In 2023, new gene therapies were approved. A small percentage...
science conference Dose limiting toxicity, in drug development; e.g. see Hydroxycarbamide Boels–Dolmans Cycling Team (Union Cycliste Internationale abbreviation)...
treatments frequently used for psoriasis include methotrexate, ciclosporin, hydroxycarbamide, fumarates such as dimethyl fumarate, and retinoids. Methotrexate and...
data sheet (SDS) ICSC 0595 Related compounds Related ureas Thiourea Hydroxycarbamide Related compounds Carbamide peroxide Urea phosphate Acetone Carbonic...
Cochrane Cystic Fibrosis and Genetic Disorders Group (ed.). "Hydroxyurea (hydroxycarbamide) for transfusion-dependent β-thalassaemia". Cochrane Database of Systematic...
agents used are vinca alkaloids such as vinblastine, cyclophosphamide, hydroxycarbamide, doxorubicin, mitoxantrone, and L-asparaginase, although combinations...
of thrombosis, oral anticoagulants and cytoreductive drugs such as hydroxycarbamide are recommended, and the patient should be treated as in primary myelofibrosis...
that VPA may offer benefits, even without improving functional score. Hydroxycarbamide (hydroxyurea) was shown effective in mouse models and subsequently...
Global Information
