Family of proteins that form the nuclear pore complex
Nucleoporin 133/155, N terminal
This domain has a 7-blade beta-propeller structure (PDB 1XKS).
Identifiers
Symbol
Nucleoporin_N
Pfam
PF08801
InterPro
IPR014908
SCOP2
1XKS / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Nucleoporin 133/155, C terminal (ACE2)
NUP133 (this domain; right) interacting with NUP107 (PDB 3CQC).
Identifiers
Symbol
Nucleoporin_C
Pfam
PF03177
InterPro
IPR007187
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
PDB
3I4R
FG repeat
Identifiers
Symbol
Nucleoporin_FG
Pfam
PF13634
Pfam clan
CL0647
InterPro
IPR025574
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC).[1] The nuclear pore complex is a massive structure embedded in the nuclear envelope at sites where the inner and outer nuclear membranes fuse, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nuclear pores enable the passive and facilitated transport of molecules across the nuclear envelope. Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family.[2] Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate. A single NPC is able to transport 60,000 protein molecules across the nuclear envelope every minute.[3]
^Doye V, Hurt E (June 1997). "From nucleoporins to nuclear pore complexes". Current Opinion in Cell Biology. 9 (3): 401–11. doi:10.1016/S0955-0674(97)80014-2. PMID 9159086.
^Han I, Oh ES, Kudlow JE (August 2000). "Responsiveness of the state of O-linked N-acetylglucosamine modification of nuclear pore protein p62 to the extracellular glucose concentration". The Biochemical Journal. 350 Pt 1 (Pt 1): 109–14. doi:10.1042/0264-6021:3500109. PMC 1221231. PMID 10926833.
^Cite error: The named reference Lodish_2013 was invoked but never defined (see the help page).
Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). The nuclear pore complex is a massive...
Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes...
Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene. The nuclear pore complex is a massive structure that extends across...
Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene. This gene encodes a member of the nucleoporin family. The protein...
proteins known as nucleoporins (Nups). Each human NPC comprises at least 456 individual protein molecules, with 34 distinct nucleoporin proteins, in 2022...
Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene. The nuclear pore complex is a massive structure that extends across the...
Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene. Bidirectional transport of macromolecules between the cytoplasm and nucleus...
Nuclear pore complex protein Nup133, or Nucleoporin Nup133, is a protein that in humans is encoded by the NUP133 gene. The nuclear envelope creates distinct...
Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene. The nuclear pore complex is a massive structure that extends across the...
Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene. The nuclear envelope creates distinct nuclear and cytoplasmic compartments...
Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene. This gene encodes a member of the nucleoporin family. The protein is localized...
Nucleoporin 188 (Nup188) is a protein that in humans is encoded by the NUP188 gene. Transport of macromolecules between the cytoplasm and nucleus occurs...
Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene. Bidirectional transport of macromolecules between the cytoplasm and nucleus...
Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene. GRCh38: Ensembl release 89: ENSG00000102900 – Ensembl, May 2017 GRCm38:...
Nucleoporin 37 (Nup37) is a protein that in humans is encoded by the NUP37 gene. Transport of macromolecules between the cytoplasm and nucleus occurs...
Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene. Nucleoporins are the main components of the nuclear pore complex (NPC)...
Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene. NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore...
Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene. Transport of macromolecules between the cytoplasm and nucleus occurs...
regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells...
of approximately 30 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis...
J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology...
complex is composed of approximately thirty different proteins known as nucleoporins.: 649 The pores are about 60–80 million daltons in molecular weight...
mammalian model systems. The proteins that constitute the NPCs, known as nucleoporins, have been shown to play a role in DNA binding and mRNA transport, making...
include chromosomes, various proteins, nuclear bodies, the nucleolus, nucleoporins, nucleotides, and nuclear speckles. The soluble, liquid portion of the...
an inner channel about 40 nm wide. The complexes contain a number of nucleoporins, proteins that link the inner and outer nuclear membranes.[citation needed]...
(December 2018). "Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease". Histochemistry and Cell Biology. 150...
H2A and H2B complex. Both anti-glycoprotein-210 (anti-gp210) and anti-nucleoporin 62 (anti-p62) antibodies are antibodies to components of the nuclear...
at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein...
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