Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules[1] involved in Ca2+-independent cellular adhesion.[2][3]
Nectins are ubiquitously expressed and have adhesive roles in a wide range of tissues such as the adherens junction of epithelia or the chemical synapse of the neuronal tissue.
^nectins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^Takai Y, Irie K, Shimizu K, Sakisaka T, Ikeda W (Aug 2003). "Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization". Cancer Science. 94 (8): 655–67. doi:10.1111/j.1349-7006.2003.tb01499.x. PMID 12901789.
^Fuchs, Anja; Colonna, M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules involved in Ca2+-independent cellular adhesion. Nectins are ubiquitously...
antibody-drug conjugate used for the treatment of urothelial cancer. It is a nectin-4-directed antibody and microtubule inhibitor conjugate. Enfortumab refers...
receptors include herpesvirus entry mediator (HVEM), nectin-1 and 3-O sulfated heparan sulfate. The nectin receptors usually produce cell-cell adhesion, to...
mediates cellular adhesion to other cells bearing its ligands, nectin molecule CD112 and nectin-like protein CD155, that are broadly distributed on normal...
found on immune cells like B or T cells, and antigen-presenting cells, or nectin-4, a cellular adhesion molecule. Once bound, the fusion, or F protein helps...
leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)". Blood. 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144...
ASG-22M6E): product candidate for the treatment of solid tumours (targets Nectin-4 in bladder, breast, lung and pancreatic cancer); developed in 50-50 partnership...
of cases. Virus enters into susceptible cells by entry receptors such as nectin-1, HVEM and 3-O sulfated heparan sulfate. Infected people who show no visible...
in aid of viral entry" (2001) "Striking similarity of murine nectin-1alpha to human nectin-1alpha (HveC) in sequence and activity as a glycoprotein D receptor...
ensure stability of synaptic components SynCAM’s (also known as Cadm or nectin-like molecules) are a specific type of synaptic CAM found in vertebrates...
including ovarian and pancreatic cancer. The conjugate consists of a human anti-nectin-4 antibody linked to the cytotoxic agent MMAE, which is released after internalization...
PMC 4222184. PMID 25080364. Noyce RS, Richardson CD (September 2012). "Nectin 4 is the epithelial cell receptor for measles virus". Trends in Microbiology...
PMC 7086627. PMID 19495937. Mueller S, Wimmer E (August 2003). "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155...
Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (May 1999). "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based...
associated with forms of anemia, myelofibrosis and thrombocythemia. CD111 Nectin-1 or Herpesvirus entry mediator C (HveC), encoded by the PVRL1 (Poliovirus...
related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005). GRCh38: Ensembl release...
A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology...
tibtech.2009.02.002. Epub 2009 Mar 25. Review. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Mühlebach MD, Mateo M, Sinn...
cell to attach to it and are then endocytosed. For example, HSV uses the nectin receptor and is then endocytosed. After endocytosis, the low pH inside the...
PMID 2538245. S2CID 44296539. Mueller, S.; Wimmer, E. (2003). "Recruitment of Nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155...
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