Istradefylline information

Istradefylline
Clinical data
Trade names	Nouriast, Nourianz
Other names	KW-6002
AHFS/Drugs.com	Monograph
License data	US DailyMed: Istradefylline;
Routes of; administration	By mouth
ATC code	N04CX01 (WHO) ;
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Protein binding	98%
Metabolism	Mainly CYP1A1, CYP3A4, and CYP3A5
Elimination half-life	64–69 hrs
Excretion	68% faeces, 18% urine
Identifiers
	IUPAC name 8-[(E)-2-(3,4-dimethoxyphenyl)vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione;
CAS Number	155270-99-8 ;
PubChem CID	5311037;
IUPHAR/BPS	5608;
DrugBank	DB11757 ;
ChemSpider	4470574 ;
UNII	2GZ0LIK7T4;
KEGG	D04641 ;
ChEMBL	ChEMBL431770 ;
CompTox Dashboard (EPA)	DTXSID7057652 ;
ECHA InfoCard	100.230.117
Chemical and physical data
Formula	C20H24N4O4
Molar mass	384.436 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1nc(n(c1C(=O)N2CC)C)\C=C\c3ccc(OC)c(OC)c3)CC;
	InChI InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+ ; Key:IQVRBWUUXZMOPW-PKNBQFBNSA-N ;
	(verify)

Istradefylline, sold under the brand name Nourianz, is a medication used as an add-on treatment to levodopa/carbidopa in adults with Parkinson's disease (PD) experiencing "off" episodes.^[2]^[3]^[4] Istradefylline reduces "off" periods resulting from long-term treatment with the antiparkinson drug levodopa.^[2] An "off" episode is a time when a patient's medications are not working well, causing an increase in PD symptoms, such as tremor and difficulty walking.^[2]

Relatively common side effects include involuntary muscle movements (dyskinesia), constipation, hallucinations, dizziness and, much like its parent molecule caffeine, nausea and sleeplessness.^[2]

The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.^[5]

^ "Nourianz- istradefylline tablet, film coated". DailyMed. Retrieved 4 January 2021.
^ ^a ^b ^c ^d "FDA approves new add-on drug to treat off episodes in adults with Parkinson's disease". U.S. Food and Drug Administration (FDA) (Press release). 27 August 2019. Archived from the original on 4 September 2019. Retrieved 29 August 2019. This article incorporates text from this source, which is in the public domain.
^ "Drug Trials Snapshots: Nourianz". U.S. Food and Drug Administration (FDA). 23 September 2019. Archived from the original on 20 November 2019. Retrieved 19 November 2019. This article incorporates text from this source, which is in the public domain.
^ Cabreira V, Soares-da-Silva P, Massano J (April 2019). "Contemporary Options for the Management of Motor Complications in Parkinson's Disease: Updated Clinical Review". Drugs. 79 (6): 593–608. doi:10.1007/s40265-019-01098-w. PMID 30905034. S2CID 85456263.
^ "New Drug Therapy Approvals 2019". U.S. Food and Drug Administration. 31 December 2019. Retrieved 15 September 2020. This article incorporates text from this source, which is in the public domain.

[1] "Nourianz- istradefylline tablet, film coated". DailyMed. Retrieved 4 January 2021.

[FDA2019-2] "FDA approves new add-on drug to treat off episodes in adults with Parkinson's disease". U.S. Food and Drug Administration (FDA) (Press release). 27 August 2019. Archived from the original on 4 September 2019. Retrieved 29 August 2019. This article incorporates text from this source, which is in the public domain.

[FDA_Snapshot-3] "Drug Trials Snapshots: Nourianz". U.S. Food and Drug Administration (FDA). 23 September 2019. Archived from the original on 20 November 2019. Retrieved 19 November 2019. This article incorporates text from this source, which is in the public domain.

[4] Cabreira V, Soares-da-Silva P, Massano J (April 2019). "Contemporary Options for the Management of Motor Complications in Parkinson's Disease: Updated Clinical Review". Drugs. 79 (6): 593–608. doi:10.1007/s40265-019-01098-w. PMID 30905034. S2CID 85456263.

[5] "New Drug Therapy Approvals 2019". U.S. Food and Drug Administration. 31 December 2019. Retrieved 15 September 2020. This article incorporates text from this source, which is in the public domain.

Istradefylline information

and 25 Related for: Istradefylline information

Istradefylline

Adenosine A2A receptor antagonist

Cocaine

Crack cocaine

Quercetin

MDMA

Caffeine

Nucleotide

Mephedrone

Purine

Adderall

Adenosine

Cytosine

Fenethylline

Adenosine receptor

Stimulant

Theophylline

Phencyclidine

Methylenedioxyphenmetrazine

ATC code N04

Theobromine

Phenolphthalein

Guanine

Ivermectin

Psychoactive drug