Global Information Lookup Global Information

Adenosine information


Adenosine
Clinical data
Trade namesAdenocard; Adenocor; Adenic; Adenoco; Adeno-Jec; Adenoscan; Adenosin; Adrekar; Krenosin
Other namesSR-96225 (developmental code name)
AHFS/Drugs.comMonograph
Pregnancy
category
  • C

(adenosine may be safe to the fetus in pregnant women)

Routes of
administration
Intravenous
ATC code
  • C01EB10 (WHO)
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityRapidly cleared from circulation via cellular uptake
Protein bindingNo
MetabolismRapidly converted to inosine and adenosine monophosphate
Elimination half-lifecleared plasma <30 seconds; half-life <10 seconds
Excretioncan leave cell intact or can be degraded to hypoxanthine, xanthine, and ultimately uric acid
Identifiers
IUPAC name
  • (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
CAS Number
  • 58-61-7 checkY
PubChem CID
  • 60961
IUPHAR/BPS
  • 2844
DrugBank
  • DB00640 checkY
ChemSpider
  • 54923 checkY
UNII
  • K72T3FS567
KEGG
  • C00212 checkY
ChEBI
  • CHEBI:16335 checkY
ChEMBL
  • ChEMBL477 checkY
CompTox Dashboard (EPA)
  • DTXSID1022558 Edit this at Wikidata
ECHA InfoCard100.000.354 Edit this at Wikidata
Chemical and physical data
FormulaC10H13N5O4
Molar mass267.245 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • n2c1c(ncnc1n(c2)[C@@H]3O[C@@H]([C@@H](O)[C@H]3O)CO)N
InChI
  • InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 checkY
  • Key:OIRDTQYFTABQOQ-KQYNXXCUSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside building blocks of RNA (and its derivative deoxyadenosine is a building block of DNA), which are essential for all life on Earth. Its derivatives include the energy carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine monophosphate (cAMP) is pervasive in signal transduction. Adenosine is used as an intravenous medication for some cardiac arrhythmias.

Adenosyl (abbreviated Ado or 5'-dAdo) is the chemical group formed by removal of the 5′-hydroxy (OH) group. It is found in adenosylcobalamin (an active form of vitamin B12[1]) and as a radical in the radical SAM enzymes.[2]

  1. ^ Butler P, Kräutler B (2006). "Biological Organometallic Chemistry of B12". Bioorganometallic Chemistry. Topics in Organometallic Chemistry. Vol. 17. pp. 1–55. doi:10.1007/3418_004. ISBN 3-540-33047-X.
  2. ^ Nelson DL, Cox MM (2005). Principles of Biochemistry (4th ed.). New York: W. H. Freeman. ISBN 0-7167-4339-6.

and 24 Related for: Adenosine information

Request time (Page generated in 0.55 seconds.)

Adenosine

Last Update:

Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached...

Word Count : 3346

Adenosine triphosphate

Last Update:

Adenosine triphosphate (ATP) is a nucleotide that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve...

Word Count : 5062

Adenosine diphosphate

Last Update:

Adenosine diphosphate (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is essential to the flow of...

Word Count : 1299

Adenosine monophosphate

Last Update:

Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide. AMP consists of a phosphate group, the sugar ribose, and the nucleobase...

Word Count : 1255

Adenosine deaminase

Last Update:

Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown...

Word Count : 3014

Cyclic adenosine monophosphate

Last Update:

Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells...

Word Count : 1612

Adenosine receptor

Last Update:

The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand. There are four...

Word Count : 1954

Adenosine A1 receptor

Last Update:

The adenosine A1 receptor (A1AR) is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as endogenous ligand. A1 receptors...

Word Count : 1973

Caffeine

Last Update:

attentional performance. Caffeine acts by blocking binding of adenosine to the adenosine A1 receptor, which enhances release of the neurotransmitter acetylcholine...

Word Count : 19766

Adenosine kinase

Last Update:

Adenosine kinase (AdK; EC 2.7.1.20) is an enzyme that catalyzes the transfer of gamma-phosphate from Adenosine triphosphate (ATP) to adenosine (Ado) leading...

Word Count : 3172

Adenosine A2A receptor

Last Update:

The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it. This protein is a member of the...

Word Count : 5102

Deamination

Last Update:

(AMPD1) Adenosine Deaminase acting on tRNA (ADAT) Adenosine Deaminase acting on dsRNA (ADAR) Double-stranded RNA-specific editase 1 (ADARB1) Adenosine Deaminase...

Word Count : 708

Adenosine deaminase deficiency

Last Update:

Adenosine deaminase deficiency (ADA deficiency) is a metabolic disorder that causes immunodeficiency. It is caused by mutations in the ADA gene. It accounts...

Word Count : 1501

Adenine

Last Update:

biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide...

Word Count : 1317

ATPase

Last Update:

ATPases (EC 3.6.1.3, Adenosine 5'-TriPhosphatase, adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, ATP hydrolase, complex V...

Word Count : 2143

Adenosine A2A receptor antagonist

Last Update:

Adenosine A2A receptor antagonists are a class of drugs that blocks adenosine at the adenosine A2A receptor. Notable adenosine A2A receptor antagonists...

Word Count : 2064

ADAR

Last Update:

double-stranded RNA-specific adenosine deaminase enzyme family are encoded by the ADAR family genes. ADAR stands for adenosine deaminase acting on RNA. This...

Word Count : 4802

Adenosine receptor agonist

Last Update:

include the neurotransmitter adenosine, its phosphates, adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP), and the...

Word Count : 249

Adenosine deaminase 2 deficiency

Last Update:

Deficiency of Adenosine deaminase 2 (DADA2) is a monogenic disease associated with systemic inflammation and vasculopathy that affects a wide variety...

Word Count : 3965

Adenosine nucleosidase

Last Update:

In enzymology, an adenosine nucleosidase (EC 3.2.2.7) is an enzyme that catalyzes the chemical reaction adenosine + H2O ⇌{\displaystyle \rightleftharpoons...

Word Count : 115

Adenosine A2 receptor

Last Update:

Two subtypes of adenosine A2 receptors are known. Both are G protein-coupled adenosine receptors: Adenosine A2A receptor Adenosine A2B receptor This disambiguation...

Word Count : 54

Creatine

Last Update:

facilitates recycling of adenosine triphosphate (ATP), primarily in muscle and brain tissue. Recycling is achieved by converting adenosine diphosphate (ADP)...

Word Count : 6794

Thiamine

Last Update:

pyrophosphate (TPP), thiamine triphosphate (ThTP), adenosine thiamine diphosphate (AThDP) and adenosine thiamine triphosphate (AThTP). They are involved...

Word Count : 5759

Adenosine diphosphatase

Last Update:

Adenosine diphosphatase may refer to: Apyrase, an enzyme Nucleoside-diphosphatase, an enzyme This disambiguation page lists articles associated with the...

Word Count : 44

PDF Search Engine © AllGlobal.net