Class of four receptor proteins to the molecule adenosine
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The adenosine receptors (or P1 receptors[1]) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand.[2] There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3; each is encoded by a different gene.
The adenosine receptors are commonly known for their antagonists caffeine, theobromine, and theophylline, whose action on the receptors produces the stimulating effects of coffee, tea and chocolate.
^Fredholm BB, Abbracchio MP, Burnstock G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U, Williams M (1997). "Towards a revised nomenclature for P1 and P2 receptors". Trends Pharmacol. Sci. 18 (3): 79–82. doi:10.1016/S0165-6147(96)01038-3. PMC 4460977. PMID 9133776.
^Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J (2001). "International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors". Pharmacol. Rev. 53 (4): 527–52. PMID 11734617.
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Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown...
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synthesis, and reduce inflammation and innate immunity and nonselective adenosinereceptor antagonists But different analogues show varying potency at the numerous...
and innate immunity and nonselective adenosinereceptor antagonists which inhibit sleepiness-inducing adenosine. However, different analogues show varying...
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of FSCPX, an irreversible A(1) adenosinereceptor antagonist, on the negative inotropic action of A(1) adenosinereceptor full agonists in isolated guinea...
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known that dimers of these receptors form heterotetramers with the dimers of dopamine D2 receptors (D2R) within striatum. Adenosine acts as an endogenous A2AR...
to an adenosine stress test, as it is a competitive antagonist of the A2A adenosinereceptor and can attenuate the vasodilatory effects adenosine.[citation...
"Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosinereceptors". Biochemical Pharmacology. 37 (4): 655–64. doi:10.1016/0006-2952(88)90139-6...
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