Isradipine information

Isradipine
Clinical data
Trade names	DynaCirc
AHFS/Drugs.com	Monograph
MedlinePlus	a693048
Pregnancy; category	C;
Routes of; administration	Oral
ATC code	C08CA03 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	15-24%
Protein binding	95%
Metabolism	100% Hepatic
Elimination half-life	8 hours
Excretion	70% Renal, 30% Fecal
Identifiers
	IUPAC name 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;
CAS Number	75695-93-1 ;
PubChem CID	3784;
DrugBank	DB00270 ;
ChemSpider	3652 ;
UNII	YO1UK1S598;
KEGG	D00349 ;
ChEMBL	ChEMBL1648 ;
CompTox Dashboard (EPA)	DTXSID4023179 ;
ECHA InfoCard	100.158.721
Chemical and physical data
Formula	C19H21N3O5
Molar mass	371.393 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC)\C3=C(\N\C(=C(\C(=O)OC(C)C)C3c1cccc2nonc12)C)C;
	InChI InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 ; Key:HMJIYCCIJYRONP-UHFFFAOYSA-N ;
	(verify)

Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack.

It was patented in 1978 and approved for medical use in 1989.^[1]

^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495.

[1] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495.

Isradipine information

and 27 Related for: Isradipine information

Isradipine

Ketamine

Calcium channel blocker toxicity

Hypertensive emergency

Calcium channel blocker

ATC code C08

Cocaine

Hypertensive urgency

List of cardiac pharmaceutical agents

Gingival enlargement

Topiramate

Benzocaine

Lidocaine

Benzonatate

Cholesterol

Pregabalin

Propranolol

Pethidine

Gabapentin

Buprenorphine

Promethazine

Amitriptyline

Lorazepam

Barbiturate

Diphenhydramine

Domperidone

Chlorphenamine