Complete set of molecular interactions in a biological cell
In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as protein–protein interactions, PPIs; or between small molecules and proteins[1]) but can also describe sets of indirect interactions among genes (genetic interactions).
Part of the DISC1 interactome with genes represented by text in boxes and interactions noted by lines between the genes. From Hennah and Porteous, 2009.[2]
The word "interactome" was originally coined in 1999 by a group of French scientists headed by Bernard Jacq.[3] Mathematically, interactomes are generally displayed as graphs. Though interactomes may be described as biological networks, they should not be confused with other networks such as neural networks or food webs.
^Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG. Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux. Sci Rep. 2018 Jul 23;8(1):11061. doi: 10.1038/s41598-018-29281-1.
^Hennah W, Porteous D (2009). Reif A (ed.). "The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes". PLOS ONE. 4 (3): e4906. Bibcode:2009PLoSO...4.4906H. doi:10.1371/journal.pone.0004906. PMC 2654149. PMID 19300510.
^Sanchez C; Lachaize C; Janody F; et al. (January 1999). "Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database". Nucleic Acids Res. 27 (1): 89–94. doi:10.1093/nar/27.1.89. PMC 148104. PMID 9847149.
In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions...
The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. The sequencing of reference genomes, in...
on histidine and 501 phosphorylated threonines and 162 tyrosines. The interactome of E. coli has been studied by affinity purification and mass spectrometry...
domain-mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is...
complement of biologically possible such interactions is known as the interactome. A systematic attempt to determine the structures of proteins representing...
the figure indicate positions in the RNA sequence. The protein-protein interactome among Orthohepevirus A proteins has been mapped by Osterman et al. (2015)...
Krabberød, Anders K.; Logares, Ramiro (2020). "The planktonic protist interactome: where do we stand after a century of research?". The ISME Journal. 14...
Chowdhury S, Hepper S, Lodi MK, Saier MH, Uetz P (April 2021). "The Protein Interactome of Glycolysis in Escherichia coli". Proteomes. 9 (2): 16. doi:10.3390/proteomes9020016...
informing of the number of protein copies in a typical cell. Studies of the interactome have identified more than 3000 protein-protein interactions. This has...
whole set of molecular interactions in the human cell, also known as the interactome, can be used for disease identification and prevention. These networks...
MT, Palzkill T, et al. (May 2008). Hall N (ed.). "The binary protein interactome of Treponema pallidum--the syphilis spirochete". PLOS ONE. 3 (5): e2292...
Chowdhury S, Hepper S, Lodi MK, Saier MH, Uetz P (April 2021). "The Protein Interactome of Glycolysis in Escherichia coli". Proteomes. 9 (2): 16. doi:10.3390/proteomes9020016...
Biological computation BioSystems (journal) Computational biology Exposome Interactome List of omics topics in biology List of systems biology modeling software...
mitochondrial protein interactome database. Reja, Rohit; et al. (3 December 2009). "MitoInteractome: Mitochondrial protein interactome database, and its application...
analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture". Nature Protocols. 16 (1). Nature Portfolio: 27–60. doi:10...
D, Daescu O (December 2007). "The human red blood cell proteome and interactome". Experimental Biology and Medicine. 232 (11): 1391–1408. doi:10.3181/0706-MR-156...
resides in can give better context for its action. Human proteome project Interactome Proteome anon. "BioPlex". harvard.edu. harvard.edu. Retrieved 24 May...
extracellular proteins. These are often collectively called the “heparin interactome” or "heparin-binding proteins", because they are isolated by affinity...
transient interactions are very important for cell biology: the human interactome is enriched in such interactions, these interactions are the dominating...
proteomics is to identify binary protein interactions, protein complexes, and interactomes. Several methods are available to probe protein–protein interactions...
PMC 8407332. PMID 34291816. De Souza, H.; Fiocchi, C.; Iliopoulos, D. The IBD interactome: An integrated view of aetiology, pathogenesis and therapy. Nat. Rev...
Visualisation of the human interactome network topology with the blue lines between proteins (represented as points) showing protein-protein interactions...
PMID 12379659. Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology. 1: 2005...
difference in the exposome, which influence disease processes through the interactome within the tissue microenvironment, differentially from person to person...
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