Computational analysis of large, complex sets of biological data
For the journal, see Bioinformatics (journal).
Not to be confused with Biological computation or Genetic algorithm.
Bioinformatics (/ˌbaɪ.oʊˌɪnfərˈmætɪks/ⓘ) is an interdisciplinary field of science that develops methods and software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, chemistry, physics, computer science, computer programming, information engineering, mathematics and statistics to analyze and interpret biological data.[1] The subsequent process of analyzing and interpreting data is referred to as computational biology.
Computational, statistical, and computer programming techniques have been used for computer simulation analyses of biological queries. They include reused specific analysis "pipelines", particularly in the field of genomics, such as by the identification of genes and single nucleotide polymorphisms (SNPs). These pipelines are used to better understand the genetic basis of disease, unique adaptations, desirable properties (esp. in agricultural species), or differences between populations. Bioinformatics also includes proteomics, which tries to understand the organizational principles within nucleic acid and protein sequences.[2]
Image and signal processing allow extraction of useful results from large amounts of raw data. In the field of genetics, it aids in sequencing and annotating genomes and their observed mutations. Bioinformatics includes text mining of biological literature and the development of biological and gene ontologies to organize and query biological data. It also plays a role in the analysis of gene and protein expression and regulation. Bioinformatics tools aid in comparing, analyzing and interpreting genetic and genomic data and more generally in the understanding of evolutionary aspects of molecular biology. At a more integrative level, it helps analyze and catalogue the biological pathways and networks that are an important part of systems biology. In structural biology, it aids in the simulation and modeling of DNA,[3] RNA,[3][4] proteins[5] as well as biomolecular interactions.[6][7][8][9]
^Gagniuc P (17 August 2021). Algorithms in Bioinformatics: Theory and Implementation (1 ed.). Wiley. pp. 1–528. ISBN 978-1-119-69796-1.
^Lesk AM (26 July 2013). "Bioinformatics". Encyclopaedia Britannica. Archived from the original on 14 April 2021. Retrieved 17 April 2017.
^ abSim AY, Minary P, Levitt M (June 2012). "Modeling nucleic acids". Current Opinion in Structural Biology. 22 (3): 273–8. doi:10.1016/j.sbi.2012.03.012. PMC 4028509. PMID 22538125.
^Dawson WK, Maciejczyk M, Jankowska EJ, Bujnicki JM (July 2016). "Coarse-grained modeling of RNA 3D structure". Methods. 103: 138–56. doi:10.1016/j.ymeth.2016.04.026. PMID 27125734.
^Kmiecik S, Gront D, Kolinski M, Wieteska L, Dawid AE, Kolinski A (July 2016). "Coarse-Grained Protein Models and Their Applications". Chemical Reviews. 116 (14): 7898–936. doi:10.1021/acs.chemrev.6b00163. PMID 27333362.
^Wong KC (2016). Computational Biology and Bioinformatics: Gene Regulation. CRC Press/Taylor & Francis Group. ISBN 978-1-4987-2497-5.
^Joyce AP, Zhang C, Bradley P, Havranek JJ (January 2015). "Structure-based modeling of protein: DNA specificity". Briefings in Functional Genomics. 14 (1): 39–49. doi:10.1093/bfgp/elu044. PMC 4366589. PMID 25414269.
^Spiga E, Degiacomi MT, Dal Peraro M (2014). "New Strategies for Integrative Dynamic Modeling of Macromolecular Assembly". In Karabencheva-Christova T (ed.). Biomolecular Modelling and Simulations. Advances in Protein Chemistry and Structural Biology. Vol. 96. Academic Press. pp. 77–111. doi:10.1016/bs.apcsb.2014.06.008. ISBN 978-0-12-800013-7. PMID 25443955.
^Ciemny M, Kurcinski M, Kamel K, Kolinski A, Alam N, Schueler-Furman O, et al. (August 2018). "Protein-peptide docking: opportunities and challenges". Drug Discovery Today. 23 (8): 1530–1537. doi:10.1016/j.drudis.2018.05.006. PMID 29733895.
definition placed bioinformatics as a field parallel to biochemistry (the study of chemical processes in biological systems). Bioinformatics and computational...
that focus on bioinformatics and computational biology. BioData Mining BioinformaticsBioinformatics and Biology Insights BMC Bioinformatics Briefings in...
The list of bioinformatics software tools can be split up according to the license used: List of proprietary bioinformatics software List of open-source...
This is a list of major bioinformatics institutions. National Center for Biotechnology Information (NCBI) European Bioinformatics Institute (EMBL-EBI) Australia...
BioNumerics Astrid Research BIOBASE BioBam Bioinformatics creator of Blast2GO Biomax Informatics AG bioinformatics services. Biovia (formerly Accelrys). Chemical...
"Databases, data tombs and dust in the wind". Bioinformatics. 24 (19): 2127–8. doi:10.1093/bioinformatics/btn464. PMID 18819940. "Volume 46 Issue D1 |...
Briefings in Bioinformatics is a peer-reviewed scientific journal covering bioinformatics, including reviews of databases and analytical tools for genetics...
BMC Bioinformatics is a peer-reviewed open access scientific journal covering bioinformatics and computational biology published by BioMed Central. It...
relevant to biotechnology and biomedicine and is an important resource for bioinformatics tools and services. Major databases include GenBank for DNA sequences...
Canadian Bioinformatics Workshops (CBW) are a series of advanced training workshops in bioinformatics, founded in 1999 in response to an identified need...
Pharmaceutical bioinformatics is a research field related to bioinformatics but with the focus on studying biological and chemical processes in the pharmaceutical...
online bioinformatics resource developed by the Laboratory of Human Retrovirology and Immunoinformatics (LHRI). All tools in the DAVID Bioinformatics Resources...
Machine learning in bioinformatics is the application of machine learning algorithms to bioinformatics, including genomics, proteomics, microarrays, systems...
MetaBase and the Bioinformatics Links Collection. Biobank Biological data Chemical database Death Domain database European Bioinformatics Institute Gene...
The International Conference on Bioinformatics (InCoB) is a scientific conference on bioinformatics aimed at scientists in the Asia Pacific region. It...
Structural bioinformatics is the branch of bioinformatics that is related to the analysis and prediction of the three-dimensional structure of biological...
The Japanese Society for Bioinformatics (JSBi) is a Japanese research society on the subjects of bioinformatics and computational biology established in...
The Bioinformatics Centre is an interdisciplinary research in bioinformatics at the University of Copenhagen (UCPH). The centre is housed in the Section...
The Australia Bioinformatics Resource (EMBL-ABR) (formerly the Bioinformatics Resource Australia - EMBL (BRAEMBL)) was a significant initiative under...
Genetics (DNA Data Bank of Japan) Swiss Institute of Bioinformatics (SIB: Expasy) Australia Bioinformatics Resource BIG Data Center (National Genomics Data...
The SIB Swiss Institute of Bioinformatics is an academic not-for-profit foundation which federates bioinformatics activities throughout Switzerland. The...
Punjab Agricultural University (PAU) is a public funded agricultural university presently headed by Dr. Satbir Singh Gosal (SS Gosal), located in Ludhiana...
alphabetical order, some examples of bioinformatics workflow management systems include: Anduril bioinformatics and image analysis BioBIKE: a Web-based...
rigorous secondary analysis of data" The SIB Bioinformatics Awards - since 2008, the Swiss Institute of Bioinformatics has delivered awards to acknowledge early...