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The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells.[1][2] The sequencing of reference genomes, in particular the Human Genome Project, has revolutionized human genetics, molecular biology, and clinical medicine. Genome-wide association study results have led to the association of genes with most Mendelian disorders,[3] and over 140 000 germline mutations have been associated with at least one genetic disease.[4] However, it became apparent that inherent to these studies is an emphasis on clinical outcome rather than a comprehensive understanding of human disease; indeed to date the most significant contributions of GWAS have been restricted to the “low-hanging fruit” of direct single mutation disorders, prompting a systems biology approach to genomic analysis.[5][6] The connection between genotype and phenotype (how variation in genotype affects the disease or normal functioning of the cell and the human body) remain elusive, especially in the context of multigenic complex traits and cancer.[7] To assign functional context to genotypic changes, much of recent research efforts have been devoted to the mapping of the networks formed by interactions of cellular and genetic components in humans, as well as how these networks are altered by genetic and somatic disease.
^Bonetta L (December 2010). "Protein-protein interactions: Interactome under construction". Nature. 468 (7325): 851–4. Bibcode:2010Natur.468..851B. doi:10.1038/468851a. PMID 21150998. S2CID 205060874.
^Stumpf MP, Thorne T, de Silva E, Stewart R, An HJ, Lappe M, Wiuf C (May 2008). "Estimating the size of the human interactome". Proceedings of the National Academy of Sciences of the United States of America. 105 (19): 6959–64. doi:10.1073/pnas.0708078105. PMC 2383957. PMID 18474861.
^Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA (January 2005). "Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders". Nucleic Acids Research. 33 (Database issue): D514–7. doi:10.1093/nar/gki033. PMC 539987. PMID 15608251.
^Stenson PD, Mort M, Ball EV, Shaw K, Phillips A, Cooper DN (January 2014). "The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine". Human Genetics. 133 (1): 1–9. doi:10.1007/s00439-013-1358-4. PMC 3898141. PMID 24077912.
^Chuang HY, Hofree M, Ideker T (2010). "A decade of systems biology". Annual Review of Cell and Developmental Biology. 26: 721–44. doi:10.1146/annurev-cellbio-100109-104122. PMC 3371392. PMID 20604711.
^Blow N (July 2009). "Systems biology: Untangling the protein web". Nature. 460 (7253): 415–8. Bibcode:2009Natur.460..415B. doi:10.1038/460415a. PMID 19606149.
^Vidal M, Cusick ME, Barabási AL (March 2011). "Interactome networks and human disease". Cell. 144 (6): 986–98. doi:10.1016/j.cell.2011.02.016. PMC 3102045. PMID 21414488.
The humaninteractome is the set of protein–protein interactions (the interactome) that occur in human cells. The sequencing of reference genomes, in particular...
In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions...
NC, Poser I, Cox J, Nagaraj N, Toyoda Y, et al. (October 2015). "A humaninteractome in three quantitative dimensions organized by stoichiometries and...
transient interactions are very important for cell biology: the humaninteractome is enriched in such interactions, these interactions are the dominating...
Q, Sahni N, et al. (November 2014). "A proteome-scale map of the humaninteractome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050...
Information center for Protein Sequences, UNIHI – Unified HumanInteractome, OPHID – Online Predicted Human Interaction Database, EcoCyc – Encyclopaedia of E...
disease gene resides in can give better context for its action. Human proteome project Interactome Proteome anon. "BioPlex". harvard.edu. harvard.edu. Retrieved...
"Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the humaninteractome". Genome Biology. 6 (5): R40...
(July 2015). "The BioPlex Network: A Systematic Exploration of the HumanInteractome". Cell. 162 (2): 425–440. doi:10.1016/j.cell.2015.06.043. PMC 4617211...
domain-mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is...
tumorigenesis in humans. Cancer proteins exhibit a network topology that is different from normal proteins in the humaninteractome. Immunoinformatics...
B. K., Obar, R. A., … Harper, J. W. (2017). Architecture of the humaninteractome defines protein communities and disease networks. Nature, 545(7655)...
Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M (October 2015). "A humaninteractome in three quantitative dimensions organized by stoichiometries and...
(July 2015). "The BioPlex Network: A Systematic Exploration of the HumanInteractome". Cell. 162 (2): 425–440. doi:10.1016/j.cell.2015.06.043. PMC 4617211...
data. The whole set of molecular interactions in the human cell, also known as the interactome, can be used for disease identification and prevention...
Q, Sahni N, et al. (November 2014). "A proteome-scale map of the humaninteractome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050...
F. (2006). "Global topological features of cancer proteins in the humaninteractome". Bioinformatics. 22 (18): 2291–2297. doi:10.1093/bioinformatics/btl390...
Mansfeld, Jörg; Buchholz, Frank; Hyman, Anthony A. (2015-10-22). "A humaninteractome in three quantitative dimensions organized by stoichiometries and...
Q, Sahni N, et al. (November 2014). "A proteome-scale map of the humaninteractome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050...
Q, Sahni N, et al. (November 2014). "A proteome-scale map of the humaninteractome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050...
PMID 14525934. Gandhi T.K.B.; et al. (March 2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets"...
Cannon JR, Ting L, Baltier K, et al. (May 2017). "Architecture of the humaninteractome defines protein communities and disease networks". Nature. 545 (7655):...
Q, Sahni N, et al. (November 2014). "A proteome-scale map of the humaninteractome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050...
Visualisation of the humaninteractome network topology with the blue lines between proteins (represented as points) showing protein-protein interactions...
Exploration of the HumanInteractome". Cell. 162 (2): 425–40. doi:10.1016/j.cell.2015.06.043. PMC 4617211. PMID 26186194. The Human Protein Atlas entry...
(July 2015). "The BioPlex Network: A Systematic Exploration of the HumanInteractome". Cell. 162 (2): 425–440. doi:10.1016/j.cell.2015.06.043. PMC 4617211...
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