Integrated stress response information

The integrated stress response is a cellular stress response conserved in eukaryotic cells that downregulates protein synthesis and upregulates specific...

ISRIB (integrated stress response inhibitor) is an experimental drug that reverses the effects of eIF2α phosphorylation with an IC50 of 5 nM. It was discovered...

Cellular stress response is the wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature...

AbbVie and Calico Life Sciences as a prodrug for modulation of the integrated stress response pathway. Arnold, F. J.; Nguyen, A. D.; Bedlack, R. S.; Bennett...

identified a molecule that inhibits the integrated stress response (ISR). The ISR is the cell's response to stresses such as viral infection, ultraviolet...

of eIF2α by EIF-2 kinases plays a key role in regulating the integrated stress response. After reperfusion following brain ischemia, there is inhibition...

Firefighter's Integrated Response Ensemble". fas.org. Retrieved 2021-04-06. Wikimedia Commons has media related to Joint Service Lightweight Integrated Suit Technology...

Collins TL, Kunjamma RB, et al. (March 2015). "Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential...

is released with a diurnal cycle and its release is increased in response to stress and low blood-glucose concentration. It functions to increase blood...

Occupational stress is psychological stress related to one's job. Occupational stress refers to a chronic condition. Occupational stress can be managed...

released upon cleavage into the cytosol, where it can activate the integrated stress response. OMA1 and the i-AAA protease share the OPA1 substrate and were...

The military stress card was a rumored "Get out of jail free" card said to have allowed United States basic training recruits to halt their training at...

neurons and hormonal and autonomic nerve responses that are relevant for immunoregulation and are integrated at brain levels (see review). On these bases...

neuronal and hormonal stress response commonly known as the fight-or-flight response. This response is also known as sympatho-adrenal response of the body, as...

organism from anticipated proteotoxic stress. Cellular stress response pathways detect and alleviate proteotoxic stress which is triggered by imbalances in...

is believed to be not only involved in the body's stress response and adaptation to chronic stress; it may also have a role in the regulation of the immune...

are integrated with emotional and cognitive states." Many biofeedback therapy devices utilize EDA as an indicator of the user's stress response with...

A vagal response to an extreme stimulus as this one, may, in very rare cases, render per se a cardiac arrest. Hypothermia and extreme stress can both...

Inflammation (from Latin: inflammatio) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants...

of general protein translation via IF2α phosphorylation, and integrated stress response via ATF4. Studies by Deretic's group from the AIM center for autophagy...

agencies could possibly take advantage of the integrated marketing communications model, due to the stress they receive from clients and budgets being reduced...

than less-resilient people) increase in stress. The speed with which this stress response returns to pre-stressor levels is also indicative of a person's...

Stress in the aviation industry is a common phenomenon composed of three sources: physiological stressors, psychological stressors, and environmental stressors...

that demand response mechanisms respond to explicit requests to shut off, whereas dynamic demand devices passively shut off when stress in the grid is...