positive regulation of type B pancreatic cell apoptotic process
negative regulation of translational initiation in response to stress
cellular response to UV
cellular response to amino acid starvation
human ageing
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
response to manganese-induced endoplasmic reticulum stress
transmembrane transport
translational initiation
protein autophosphorylation
regulation of translation
regulation of translational initiation in response to stress
negative regulation of guanyl-nucleotide exchange factor activity
positive regulation of neuron death
protein biosynthesis
stress granule assembly
cellular response to oxidative stress
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1965
13665
Ensembl
ENSG00000134001
ENSMUSG00000021116
UniProt
P05198
Q6ZWX6
RefSeq (mRNA)
NM_004094
NM_026114
RefSeq (protein)
NP_004085
NP_080390
Location (UCSC)
Chr 14: 67.36 – 67.39 Mb
Chr 12: 78.91 – 78.93 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000134001 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021116 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ernst H, Duncan RF, Hershey JW (January 1987). "Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA". The Journal of Biological Chemistry. 262 (3): 1206–12. doi:10.1016/S0021-9258(19)75772-X. PMID 2948954.
^"Entrez Gene: EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa". National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2010-10-05.
factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene. The protein encoded by this gene is the alpha (α) subunit of the translation...
eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma (subunit 3, EIF2S3) subunit. Once...
phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular...
heat shock. EIF2AK1 exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming...