Cellular stress response is the wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature, exposure to toxins, and mechanical damage. Cellular stress responses can also be caused by some viral infections.[1] The various processes involved in cellular stress responses serve the adaptive purpose of protecting a cell against unfavorable environmental conditions, both through short term mechanisms that minimize acute damage to the cell's overall integrity, and through longer term mechanisms which provide the cell a measure of resiliency against similar adverse conditions.[2]
^Nakagawa K, Lokugamage KG, Makino S (2016-01-01). Ziebuhr J (ed.). "Viral and Cellular mRNA Translation in Coronavirus-Infected Cells". Advances in Virus Research. Coronaviruses. 96. Academic Press: 165–192. doi:10.1016/bs.aivir.2016.08.001. ISBN 9780128047361. PMC 5388242. PMID 27712623.
Cellularstressresponse is the wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature...
The integrated stressresponse is a cellularstressresponse conserved in eukaryotic cells that downregulates protein synthesis and upregulates specific...
The mitochondrial unfolded protein response (UPRmt) is a cellularstressresponse related to the mitochondria. The UPRmt results from unfolded or misfolded...
understanding of cellular aging molecular pathways. Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include...
The heat shock response (HSR) is a cell stressresponse that increases the number of molecular chaperones to combat the negative effects on proteins caused...
The bacterial stressresponse enables bacteria to survive adverse and fluctuating conditions in their immediate surroundings. Various bacterial mechanisms...
include improve lifespan and fitness, by activating the animal's cellularstressresponse. This may be useful to evolve, as it gives possible cues about...
species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.[citation...
In cellular biology, stress granules are biomolecular condensates in the cytosol composed of proteins and RNAs that assemble into 0.1–2 μm membraneless...
In cell biology and pathophysiology, cellular adaptation refers to changes made by a cell in response to adverse or varying environmental changes. The...
part of a cell's own repair system, called the "cellularstressresponse" or the "heat-shock response". Recently, there are several studies that suggest...
important to the proper functioning of the immune system and in the cellularstressresponse. The X-box binding protein 1 (XBP1) is a transcription factor containing...
unfolded protein response (UPR) is a cellularstressresponse related to the endoplasmic reticulum. The UPR is activated in response to an accumulation...
organism from anticipated proteotoxic stress. Cellularstressresponse pathways detect and alleviate proteotoxic stress which is triggered by imbalances in...
work demonstrating that TLR4 is the LPS receptor. As part of the cellularstressresponse, superoxide is one of the major reactive oxygen species induced...
Roberson RS, Taft J, Wu DY (2003). "Human BAG-1 proteins bind to the cellularstressresponse protein GADD34 and interfere with GADD34 functions". Mol. Cell...
activate death receptors, stimulate apoptotic pathways, or initiate cellularstressresponse in the endoplasmic reticulum. These lipotoxic effects have been...
crucial biological processes, including metabolic processes and cellularstressresponse. Lysine propionylation was first identified on histone proteins...
"Intracellular water homeostasis and the mammalian cellular osmotic stressresponse". Journal of Cellular Physiology. 206 (1): 9–15. doi:10.1002/jcp.20445...
is thought to function in the cellularstressresponse pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of...
suggest that inhibition of V-ATPase with bafilomycin can induce a cellularstressresponse, including autophagy and eventual apoptosis. These somewhat contradictory...
allow for the cellular defense against pro-oxidative conditions. There is a feedback regulation balance between reductive and oxidative stress where chronic...
of oxidants leads to the acquisition of cellular resistance to a subsequent lethal oxidative stress. In response to an increased flux of hydrogen peroxide...
or stress. Mitophagy promotes the turnover of mitochondria and prevents the accumulation of dysfunctional mitochondria which can lead to cellular degeneration...
directly associated to stress condition because there is often an immediate increase in polyamine levels in response to stress, but after a while polyamine...
immune responses. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress. NRF2...
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