For the airport with IATA code IEG, see Zielona Góra Airport.
Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli. They represent a standing response mechanism that is activated at the transcription level in the first round of response to stimuli, before any new proteins are synthesized. IEGs are distinct from "late response" genes, which can only be activated later, following the synthesis of early response gene products. Thus IEGs have been called the "gateway to the genomic response". The term can describe viral regulatory proteins that are synthesized following viral infection of a host cell, or cellular proteins that are made immediately following stimulation of a resting cell by extracellular signals.
In their role as "gateways to genomic response", many IEG products are natural transcription factors or other DNA-binding proteins. However, other important classes of IEG products include secreted proteins, cytoskeletal proteins, and receptor subunits. Neuronal IEGs are used prevalently as a marker to track brain activities in the context of memory formation and development of psychiatric disorders.[1] IEGs are also of interest as a therapeutic target for treatment of human cytomegalovirus.[2]
^Gallo FT, Katche C, Morici JF, Medina JH, Weisstaub NV (2018-04-25). "Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc". Frontiers in Behavioral Neuroscience. 12: 79. doi:10.3389/fnbeh.2018.00079. PMC 5932360. PMID 29755331.
^Adamson CS, Nevels MM (January 2020). "Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function". Viruses. 12 (1): 110. doi:10.3390/v12010110. PMC 7019229. PMID 31963209.
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Immediateearlygenes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli. They represent a...
Immediateearly response 2 is a protein that in humans is encoded by the IER2 gene. GRCh38: Ensembl release 89: ENSG00000160888 – Ensembl, May 2017 GRCm38:...
PMID 3131879. Pfaus, J.G.; Heeb, M.M. (1997). "Implications of immediate-earlygene induction in the brain following sexual stimulation of female and...
persistent marker (e.g. beta-galactosidase) under control of the immediateearlygene fos. This mouse strain allows the stable labeling of activated neurons...
cascade, expression and process of both transcription factors and immediateearlygenes, are susceptible to disruptions. Disruptions caused by specific...
signal-responsive TOP2B-induced double-strand breaks in immediateearlygenes. Also the messenger RNAs of many genes that had been subjected to methylation-controlled...
classes of genes in the phage genome that regulate whether the lytic or lysogenic cycles will emerge. The first class is the immediateearlygenes, the second...
Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of ImmediateEarlyGene Expression within the Prelimbic Prefrontal Cortex and Is Required...
produced as part of an arc fault Arc (protein), a name of product of an immediateearlygene, also called Arg3.1 Reflex arc, a neural pathway that controls a...
stages. Immediateearlygenes are transcribed right after infection and their gene products activate transcription of the earlygenes. Earlygene products...
Radiation-inducible immediate-earlygene IEX-1 is a protein that in humans is encoded by the IER3 gene. This gene functions in the protection of cells...
of the others, as indexed by the induced expression of c-Fos, an immediateearlygene. Furthermore, inhibition of one hotspot results in the blunting of...
growth factor/cytokine induced genes. THOC5, thereby contributes to the 3′ processing and/or export of immediate-earlygenes induced by extracellular stimuli...
polymerase to read through the terminators located at the ends of the immediateearlygenes. Another antitermination protein, pQ, is required later in phage...
complex with the host transcription factors Oct-1 and HCF to induce immediateearlygene transcription in the herpes simplex viruses. VP16 is a strong transactivator...
expression of parental behavior, as evidenced by increases in the immediateearlygene c-fos, in experienced rat mothers or fathers when compared to controls...
that in humans is encoded by the NPAS4 gene. The NPAS4 gene is a neuronal activity-dependent immediateearlygene that has been identified as a transcription...
the mole rats were exposed to a magnetic field, the greater the immediateearlygene expression within the InGi. Magnetic fields appear to play a role...
damage the neurons. In other research, variation in the expression of immediateearlygene and heat shock protein was identified as causing selective vulnerability...
of the others, as indexed by the induced expression of c-Fos, an immediateearlygene. Furthermore, inhibition of one hotspot results in the blunting of...
memory-related immediateearlygenes (among other genes) in neurons after neuron activation. These double-strand breaks allow the genes to be transcribed...
pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediateearlygene 1 and the 'a' sequence". The Journal of General Virology. 72 ( Pt...
for processing the information being learned. Such genes are referred to as immediateearlygenes (IEGs). TOP2B activity is essential for the expression...
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