DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
nucleotide binding
DNA binding
histone deacetylase binding
chromatin binding
isomerase activity
metal ion binding
DNA topoisomerase activity
protein C-terminus binding
protein heterodimerization activity
enzyme binding
ATP binding
protein kinase C binding
ribonucleoprotein complex binding
Cellular component
cytosol
nucleoplasm
heterochromatin
nucleolus
nucleus
cytoplasm
ribonucleoprotein complex
viral integration complex
Biological process
resolution of meiotic recombination intermediates
axonogenesis
DNA metabolic process
neuron migration
forebrain development
mitotic DNA integrity checkpoint signaling
sister chromatid segregation
DNA topological change
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7155
21974
Ensembl
ENSG00000077097
ENSMUSG00000017485
UniProt
Q02880
Q64511
RefSeq (mRNA)
NM_001068 NM_001330700
NM_009409
RefSeq (protein)
NP_001059 NP_001317629
NP_033435
Location (UCSC)
Chr 3: 25.6 – 25.66 Mb
Chr 14: 6.03 – 6.1 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000077097 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000017485 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tan KB, Dorman TE, Falls KM, Chung TD, Mirabelli CK, Crooke ST, Mao J (January 1992). "Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively". Cancer Research. 52 (1): 231–234. PMID 1309226.
^Jenkins JR, Ayton P, Jones T, Davies SL, Simmons DL, Harris AL, et al. (November 1992). "Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24". Nucleic Acids Research. 20 (21): 5587–5592. doi:10.1093/nar/20.21.5587. PMC 334390. PMID 1333583.
DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene. This gene encodes a DNA topoisomerase, an enzyme that controls and...
appear to depend on double-strand breaks initiated by topoisomerase 2β (TOP2B) for activation. The induction of particular double-strand breaks is specific...
neurons are activated in vitro, just 22 of TOP2B-induced double-strand breaks occur in their genomes. Such TOP2B-induced double-strand breaks are accompanied...
neurons are activated in vitro, just 22 of TOP2B-induced double-strand breaks occur in their genomes. Such TOP2B-induced double-strand breaks are accompanied...
the genes at which it occurs, the DNA double-stranded break induced by TOP2B is thought to be part of the process of regulation of gene expression. DNA...
reviewed in 2022. These mechanisms include, for instance, signal-responsive TOP2B-induced double-strand breaks in immediate early genes. More than 100 DNA...
to correlate with cell proliferation - but β did not. Topoisomerase II TOP2B - Topoisomerase II beta Gene duplication Ataxia-telangiectasia TOPBP1 GRCh38:...
topoisomerase II. She was a co-discoverer of DNA topoisomerase IIbeta (TOP2B). Her most-cited article, Caroline Austin, KL Marsh. "Eukaryotic DNA topoisomerase...
Albadine, R., Gurel, B., ... Yegnasubramanian, S. (2010). Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nature...
DAXX, DNMT3B, P53, PIAS1, PML, SAE2, SP1, TDG, TNFRSF1A, TNFRSF6, TOP2A, TOP2B, and UBE2I, Heart failure is a process by which the heart’s pumping ability...
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