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Hyperbilirubinemia is a clinical condition describing an elevation of blood bilirubin level due to the inability to properly metabolise or excrete bilirubin, a product of erythrocytes breakdown. In severe cases, it is manifested as jaundice, the yellowing of tissues like skin and the sclera when excess bilirubin deposits in them.[1] The US records 52,500 jaundice patients annually.[2] By definition, bilirubin concentration of greater than 3 mg/ml is considered hyperbilirubinemia, following which jaundice progressively develops and becomes apparent when plasma levels reach 20 mg/ml.[3] Rather than a disease itself, hyperbilirubinemia is indicative of multifactorial underlying disorders that trace back to deviations from regular bilirubin metabolism. Diagnosis of hyperbilirubinemia depends on physical examination, urinalysis, serum tests, medical history and imaging to identify the cause. Genetic diseases, alcohol, pregnancy and hepatitis viruses affect the likelihood of hyperbilirubinemia. Causes of hyperbilirubinemia mainly arise from the liver. These include haemolytic anaemias, enzymatic disorders, liver damage and gallstones. Hyperbilirubinemia itself is often benign. Only in extreme cases does kernicterus, a type of brain injury, occur. Therapy for adult hyperbilirubinemia targets the underlying diseases but patients with jaundice often have poor outcomes.[4]
^Memon, Naureen; Weinberger, Barry I; Hegyi, Thomas; Aleksunes, Lauren M (2016). "Inherited disorders of bilirubin clearance". Pediatric Research. 79 (3): 378–386. doi:10.1038/pr.2015.247. ISSN 0031-3998. PMC 4821713. PMID 26595536.
^"NAMCS/NHAMCS - Ambulatory Health Care Data Homepage". www.cdc.gov. 2022-03-16. Retrieved 2022-04-10.
^"Jaundice - Hepatic and Biliary Disorders". MSD Manual Professional Edition. Retrieved 2022-03-29.
^Sullivan, Jeremy I.; Rockey, Don C. (2017). "Diagnosis and evaluation of hyperbilirubinemia". Current Opinion in Gastroenterology. 33 (3): 164–170. doi:10.1097/MOG.0000000000000354. ISSN 0267-1379. PMID 28333690. S2CID 11852519.
and 24 Related for: Hyperbilirubinemia in adults information
Hyperbilirubinemia is a clinical condition describing an elevation of blood bilirubin level due to the inability to properly metabolise or excrete bilirubin...
various pathological situations. Hyperbilirubinemia is a higher-than-normal level of bilirubin in the blood. Hyperbilirubinemia may refer to increased levels...
Shilpa Grover (eds.). "Diagnostic approach to the adult with jaundice or asymptomatic hyperbilirubinemia". UpToDate. Retrieved 2019-07-17. Glucuronosyltransferase...
excrete bilirubin as quickly as an adult. This causes an accumulation of bilirubin in the blood (hyperbilirubinemia), leading to the symptoms of jaundice...
jaundice or asymptomatic hyperbilirubinemia". UpToDate. Fargo MV, Grogan SP, Saguil A (February 2017). "Evaluation of Jaundice inAdults". American Family Physician...
When hyperbilirubinemia increases past a mild level, it leads to jaundice, raising the risk of progressing to kernicterus. When this happens inadults, it...
this may occur in children with hyperbilirubinemia, tooth discoloration due to hyperbilirubinemia is not observed in individuals with adult-onset liver disease...
were attended to in nurseries without specialized resuscitation equipment. In 1968, Dr. Jerold Lucey demonstrated that hyperbilirubinemia of prematurity...
hypoglycemia and exaggerated jaundice (both direct and indirect hyperbilirubinemia).[citation needed] Even congenital GH deficiency does not usually...
it is known as hyperbilirubinemia of the newborn (neonatal jaundice) and requires light therapy to reduce the amount of bilirubin in the blood. Pathological...
failure and hepatitis are the most etiological in liver-genesis hyperbilirubinemia. In case of hyperbilirubinemia due to intrahepatic or extrahepatic bile ducts...
circulation, leading to hemoglobinemia and increasing the risk of ensuing hyperbilirubinemia. Intravascular hemolysis is the state when the red blood cell ruptures...
include severe anemia, normal MCV (mean corpuscular volume), and hyperbilirubinemia (from increased red cell destruction) that can be of the conjugated...
skin or the whites of the eyes owing to hyperbilirubinemia Bile is removed from the bloodstream and excreted in the urine, giving it a dark amber color...
(hypersplenism) and gallstones (due to hyperbilirubinemia from peripheral hemolysis). These complications are mostly found in thalassemia major and intermedia...
immaturity: respiratory distress apnea temperature instability hypoglycemia hyperbilirubinemia poor feeding At 34–35 weeks, the brain weight is only about 2⁄3 that...
circulation, leading to hemoglobinemia and increasing the risk of ensuing hyperbilirubinemia. Intravascular hemolysis may occur when red blood cells are targeted...
"The effects of light therapy on depression and sleep disruption in older adultsin a long-term care facility". International Journal of Nursing Practice...
with this condition. Jaundice is caused by hyperbilirubinemia, or abnormally high levels of bilirubin in the blood. Bilirubin is usually bound to albumin...
of hypoglycemia in the neonatal period, independent of whether the mother has diabetes. Hypoglycemia, as well as hyperbilirubinemia and polycythemia...
site reactions. Slow heart rate, skin reactions such as pruritus, hyperbilirubinemia, hypothyroidism, dizziness and dyspnoea are also fairly common (more...
induction of meconium evacuation using per rectal laxatives on neonatal hyperbilirubinemiain term infants: a systematic review of randomized controlled trials"...
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