Liver function tests (LFTs or LFs), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient's liver.[1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin, bilirubin (direct and indirect), and others. The liver transaminases aspartate transaminase (AST or SGOT) and alanine transaminase (ALT or SGPT) are useful biomarkers of liver injury in a patient with some degree of intact liver function.[2][3][4]
Most liver diseases cause only mild symptoms initially, but these diseases must be detected early. Hepatic (liver) involvement in some diseases can be of crucial importance. This testing is performed on a patient's blood sample. Some tests are associated with functionality (e.g., albumin), some with cellular integrity (e.g., transaminase), and some with conditions linked to the biliary tract (gamma-glutamyl transferase and alkaline phosphatase). Because some of these tests do not measure function, it is more accurate to call these liver chemistries or liver tests rather than liver function tests.[5]
Several biochemical tests are useful in the evaluation and management of patients with hepatic dysfunction. These tests can be used to detect the presence of liver disease. They can help distinguish among different types of liver disorders, gauge the extent of known liver damage, and monitor the response to treatment. Some or all of these measurements are also carried out (usually about twice a year for routine cases) on individuals taking certain medications, such as anticonvulsants, to ensure that these medications are not adversely impacting the person's liver.[citation needed]
^Lee, Mary (10 March 2009). Basic Skills in Interpreting Laboratory Data. ASHP. p. 259. ISBN 978-1-58528-180-0. Retrieved 5 August 2011.
^Johnston DE (1999). "Special considerations in interpreting liver function tests". Am Fam Physician. 59 (8): 2223–30. PMID 10221307.
^McClatchey, Kenneth D. (2002). Clinical laboratory medicine. Lippincott Williams & Wilkins. p. 288. ISBN 978-0-683-30751-1.
^Mengel, Mark B.; Schwiebert, L. Peter (2005). Family medicine: ambulatory care & prevention. McGraw-Hill Professional. p. 268. ISBN 978-0-07-142322-9.
^Kwo, Paul Y.; Cohen, Stanley M.; Lim, Joseph K. (January 2017). "ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries". American Journal of Gastroenterology. 112 (1): 18–35. doi:10.1038/ajg.2016.517. ISSN 0002-9270. PMID 27995906. S2CID 23788795.
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