RESF1 information

RESF1
Identifiers
Aliases	RESF1, C12orf35, UTA2-1, GET, retroelement silencing factor 1, KIAA1551
External IDs	MGI: 1914496 HomoloGene: 19251 GeneCards: RESF1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	31,993,107 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	149,237,161 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; lymph node; ; jejunal mucosa; ; blood; ; spleen; ; monocyte; ; secondary oocyte; ; germinal epithelium; ; appendix; ; trabecular bone;
	Top expressed in
	cumulus cell; ; secondary oocyte; ; blood; ; internal carotid artery; ; external carotid artery; ; uterus; ; vas deferens; ; abdominal wall; ; right lung; ; lymph node;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone binding;
Cellular component	gamma-tubulin complex; nucleus;
Biological process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of DNA methylation-dependent heterochromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	55196
	67246
	ENSG00000174718
	ENSMUSG00000032712
	Q9HCM1
	Q5DTW7
	NM_018169
	NM_001289661; NM_001289662; NM_026054
	NP_060639
	NP_001276590; NP_001276591; NP_080330
	Wikidata
View/Edit Human	View/Edit Mouse

Retroelement silencing factor 1 is a protein that in humans is encoded by the RESF1 gene. RESF1 is broadly expressed in the lymph nodes, ovaries, appendix and spleen.^[5] RESF1 shows characteristics of being a minor histocompatibility antigen, as well as tumor suppressor capabilities.^[6]^[7] The high expression in the lymph nodes and spleen indicate function in the immune system.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174718 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032712 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "uncharacterized protein RESF1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-04.
^ Roopenian D, Choi EY, Brown A (December 2002). "The immunogenomics of minor histocompatibility antigens". Immunological Reviews. 190: 86–94. doi:10.1034/j.1600-065x.2002.19007.x. PMID 12493008. S2CID 22243976.
^ Oostvogels R, Minnema MC, van Elk M, Spaapen RM, te Raa GD, Giovannone B, Buijs A, van Baarle D, Kater AP, Griffioen M, Spierings E, Lokhorst HM, Mutis T (March 2013). "Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1". Leukemia. 27 (3): 642–9. doi:10.1038/leu.2012.277. PMC 3593180. PMID 23079962.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174718 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032712 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] "uncharacterized protein RESF1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-04.

[pmid12493008-6] Roopenian D, Choi EY, Brown A (December 2002). "The immunogenomics of minor histocompatibility antigens". Immunological Reviews. 190: 86–94. doi:10.1034/j.1600-065x.2002.19007.x. PMID 12493008. S2CID 22243976.

[pmid23079962-7] Oostvogels R, Minnema MC, van Elk M, Spaapen RM, te Raa GD, Giovannone B, Buijs A, van Baarle D, Kater AP, Griffioen M, Spierings E, Lokhorst HM, Mutis T (March 2013). "Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1". Leukemia. 27 (3): 642–9. doi:10.1038/leu.2012.277. PMC 3593180. PMID 23079962.