Endoplasmic reticulum membrane protein complex information
Endoplasmic reticulum membrane protein complex
Identifiers
Symbol
EMC
Membranome
637
The endoplasmic reticulum membrane protein complex (EMC) is a putative endoplasmic reticulum-resident membrane protein (co-)chaperone.[1] The EMC is evolutionarily conserved in eukaryotes (animals, plants, and fungi), and its initial appearance might reach back to the last eukaryotic common ancestor (LECA).[2] Many aspects of mEMC biology and molecular function remain to be studied.
^Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M (March 2009). "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum". Science. 323 (5922): 1693–7. Bibcode:2009Sci...323.1693J. doi:10.1126/science.1167983. PMC 2877488. PMID 19325107.
^Wideman JG (25 August 2015). "The ubiquitous and ancient ER membrane protein complex (EMC): tether or not?". F1000Research. 4: 624. doi:10.12688/f1000research.6944.2. PMC 4602282. PMID 26512320.
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The endoplasmicreticulummembraneproteincomplex (EMC) is a putative endoplasmicreticulum-resident membraneprotein (co-)chaperone. The EMC is evolutionarily...
The endoplasmicreticulum (ER) is a part of a transportation system of the eukaryotic cell, and has many other important functions such as protein folding...
Most secretory and membrane-bound proteins are co-translationally translocated. Proteins that reside in the endoplasmicreticulum (ER), golgi or endosomes...
include: the nuclear membrane, the endoplasmicreticulum, the Golgi apparatus, lysosomes, vesicles, endosomes, and plasma (cell) membrane among others. The...
molecular chaperone located in the lumen of the endoplasmicreticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains...
the plasma membrane. In eucaryotic cells, new phospholipids are manufactured by enzymes bound to the part of the endoplasmicreticulummembrane that faces...
the membrane via lipid modifications such as palmitoylation. Tail-anchored proteins can be inserted into the plasma membrane, endoplasmicreticulum, mitochondria...
are synthesized in a complex pathway involving exchange of lipid precursors between the endoplasmicreticulum and inner membrane of the plastid envelope...
Emergency Medical Care, a Canadian ambulance service Endoplasmicreticulummembraneproteincomplex Environmental Modeling Center, one of the United States...
transmembrane protein is a type of integral membraneprotein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways...
also translocate and integrate membraneproteins in the correct orientation into the membrane of the endoplasmicreticulum. The mechanism of this process...
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usually about 10–50 nm wide. The outer nuclear membrane is continuous with the endoplasmicreticulummembrane. The nuclear envelope has many nuclear pores...
alpha and associated calnexin are major calcium binding proteins of the endoplasmicreticulummembrane". J Biol Chem. 226 (29): 19599–610. doi:10.1016/S0021-9258(18)55036-5...
composition, and only the outer membrane is continuous with the endoplasmicreticulum (ER) membrane. Like the ER, the outer membrane also possesses ribosomes...
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calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmicreticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR...
encoded by the autosomal gene PDIA3 in humans. This protein localizes to the endoplasmicreticulum (ER) and interacts with lectin chaperones calreticulin...
intracellular proteins are synthesized in the cytoplasm and membrane-bound or secreted proteins in the endoplasmicreticulum, the specifics of how proteins are...
enzymes, and have more than 50 membraneproteins. Enzymes of the lysosomes are synthesized in the rough endoplasmicreticulum and exported to the Golgi apparatus...
structural proteins and various virus-specific accessory proteins. M is translated by membrane-bound polysomes to be inserted into the endoplasmicreticulum (ER)...
membrane can associate with the endoplasmicreticulum (ER) membrane, in a structure called MAM (mitochondria-associated ER-membrane). This is important in the...
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