A FFAT motif (FFAT being an acronym for two phenylalanines (FF) in an acidic tract[nb 1]) is a protein sequence motif of six defined amino acids plus neighbouring residues that binds to proteins in the VAP protein family.[1]
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^Loewen CJ, Roy A, Levine TP (May 2003). "A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP". The EMBO Journal. 22 (9): 2025–35. doi:10.1093/emboj/cdg201. PMC 156073. PMID 12727870.
A FFATmotif (FFAT being an acronym for two phenylalanines (FF) in an acidic tract) is a protein sequence motif of six defined amino acids plus neighbouring...
N-terminal MSP-homologous part of VAPA is able to bind to the FFATmotif, a particular sequence motif shared by several lipid binding proteins including oxysterol-binding...
Nir2 and Nir3: an N-terminal FFATmotif, a DDHD domain, and a C-terminal Lipin/Ndel/Smp2 (LNS2) domain. The FFATmotif is made up of double phenylalanines...
containing 2 (MOSPD2), which has all the elements of VAP, and like them binds FFATmotifs, but has at its N-terminus a CRAL-TRIO domain that can bind and transfer...
this interaction is regulated by phosphorylation of a serine in its FFATmotif. The closest homolog to STARD3 is the steroidogenic acute regulatory protein...
can interact with the ER-resident VAP proteins Scs2/Scs22 through its FFATmotif (two phenylalanines on an acidic tract), ultimately activating ER-localized...
vesicle trafficking. Like VAPA, VAPB binds to proteins that contain a FFATmotif. Considerable interest in VAPB has arisen because mutations in this protein...
natural D-erythro isomer of ceramide and extract it from the membrane. FFATmotif (two phenylalanines in an acidic tract, that has a conserved sequence...
and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs". Cell Reports. 33 (10): 108475. doi:10.1016/j.celrep.2020.108475...
consisting of an N-terminal pleckstrin homology (PH) domain, a central FFATmotif (two phenylalanines in an acidic track), and a C-terminal lipid transport...
interact with: GSK3B, PPP1CA, PRKAR2A, PRKAR2B. VAPB. Binding is via a FFATmotif in the N-terminal portion of AKAP11, similar to that found in AKAP3. GRCh38:...
and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs". Cell Reports. 33 (10): 108475. doi:10.1016/j.celrep.2020.108475...
Filmproduktionsgesellschaft, Popular-Film, DNS-Filmproduktion, Film-Fernsehen-Autoren-Team (FFAT), Dieter Geissler Filmproduktion, Don Geraghty Film Services, and ZDF. Principal...
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