In the management of HIV/AIDS, HIV capsid inhibitors are antiretroviral medicines that target the capsid shell of the virus. Most current antiretroviral drugs used to treat HIV do not directly target the viral capsid.[1] These have also been termed "Capsid-targeting Antivirals", "Capsid Effectors", and "Capsid Assembly Modulators (CAMs)". Because of this, drugs that specifically inhibit the HIV capsid are being developed in order to reduce the replication of HIV, and treat infections that have become resistant to current antiretroviral therapies.[2]
^"FDA-Approved HIV Medicines | NIH". hivinfo.nih.gov. Retrieved 2023-05-25.
^McFadden WM, Snyder AA, Kirby KA, Tedbury PR, Raj M, Wang Z, Sarafianos SG (December 2021). "Rotten to the core: antivirals targeting the HIV-1 capsid core". Retrovirology. 18 (1): 41. doi:10.1186/s12977-021-00583-z. PMC 8693499. PMID 34937567.
and 24 Related for: HIV capsid inhibition information
In the management of HIV/AIDS, HIVcapsid inhibitors are antiretroviral medicines that target the capsid shell of the virus. Most current antiretroviral...
release of the HIVcapsid into the cell. Entry to the cell begins through interaction of the trimeric envelope complex (gp160 spike) on the HIV viral envelope...
of the immunoproteasome enables human TRIM5α for effective capsid-dependent inhibition of HIV-1 DNA synthesis and infection. GRCh38: Ensembl release 89:...
protein cage called the capsid, which is wrapped in a lipid bilayer called the envelope. The envelope is joined to the capsid by means of a tegument....
Silva, Diane M.; Kast, W. Martin (2009-11-15). "A major role for the minor capsid protein of human papillomavirus type 16 in immune escape". Journal of Immunology...
different depending on the type of virus it is. A virus with a nonenveloped capsid enters the cell by attaching to the attachment factor located on a host...
This capsid has 161 capsomers consisting of 150 hexons and 11 pentons, as well as a portal complex that allows entry and exit of DNA into the capsid. All...
and sometimes a few enzymes stored in a capsule made of protein (called a capsid), and sometimes covered with a lipid layer (sometimes called an 'envelope')...
acids within the capsid of HIV-1, helps integrate the viral RNA into budding virions, and is intimately involved in the replication of HIV-1 in both the...
Wire, where he is an associate editor. His 2016 book Capsid: A Love Song won the POZ Award for best HIV writing (fiction/poetry) and was a finalist for a...
assembly of infectious virus particles. HIV assembly is a two-stage process involving an intermediate immature capsid that undergoes a structurally dramatic...
of the HIV and increase the efficacy of the drug. Galectin-3 binds TRIM5α, a cytosolic restriction factor against HIV acting during HIVcapsid uncoating...
the mature capsid lattice. These studies identify IP6 as a naturally occurring small molecule that promotes both assembly and maturation of HIV-1. IP6 has...
cellular membrane, releasing tegument proteins and the naked capsid into the cytoplasm. The capsid travels to a nuclear pore, likely along cytoskeletal microtubules...
viral infection, NAbs can bind to glycoproteins of enveloped viruses or capsid proteins of non-enveloped viruses. Furthermore, neutralizing antibodies...
blocking a stable human protein that HIV uses to infect T cells. Its advantages include its competitive inhibition, a high affinity of UB-421 to CD4 T...
composed of five expression units: from the N terminal to the C terminal - Capsid, E3, E2, 6K and E1. A sub genomic positive strand RNA - the 26S RNA - is...
icosahedral nucleocapsid and it has function in replication of the virus. Capsid formation is the main factor for infection of the cell. HBcAg contributes...
lipids and forming ion channels in the inner capsid with experimental evidence showing inhibition of HIV and HSV. However, surfactin can only degrade...
Meister G, Landthaler M, Dorsett Y, Tuschl T (Mar 2004). "Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing". RNA. 10 (3): 544–50. doi:10...
roll' β-structure, typical for the TNF family, but also found in viral capsid proteins. TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a;...
alternative reading frame of the P-coding mRNA, is also associated with a viral capsid. It is present in SeV virions at relatively low levels (40 molecules/genome)...
over the course of one month. The attachment and inhibition of HIV reverse transcriptase by DPV prevent HIV genome replication within the host upon initial...
1997). "Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus". The Journal of Cell Biology. 136 (5): 1007–1021. doi:10...
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