RNA silencing or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated by non-coding RNAs such as microRNAs. RNA silencing may also be defined as sequence-specific regulation of gene expression triggered by double-stranded RNA (dsRNA).[1] RNA silencing mechanisms are conserved among most eukaryotes.[2] The most common and well-studied example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the degradation of complementary messenger RNA. Other classes of small RNA have been identified, including piwi-interacting RNA (piRNA)[3] and its subspecies repeat associated small interfering RNA (rasiRNA).[4]
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^Monga I, Banerjee I (November 2019). "Computational Identification of piRNAs Using Features Based on RNA Sequence, Structure, Thermodynamic and Physicochemical Properties". Current Genomics. 20 (7): 508–518. doi:10.2174/1389202920666191129112705. PMC 7327968. PMID 32655289.
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microRNAs. RNAsilencing may also be defined as sequence-specific regulation of gene expression triggered by double-stranded RNA (dsRNA). RNAsilencing mechanisms...
post-transcriptional silencing occurs as protein translation is prevented. Transcription can be inhibited via the pre-transcriptional silencing mechanism of RNAi...
in RNAsilencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in mRNA molecules, then silence said...
intermediate RNA, they are targeted by a dicer enzyme and cleaved into siRNAs that are then loaded onto the RNA-induced silencing complex. The viroid siRNAs contain...
Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene. Gene silencing can occur during either transcription...
interfering RNA (siRNA), sometimes known as short interfering RNA or silencingRNA, is a class of double-stranded RNA at first non-coding RNA molecules...
role in RNAsilencing processes as essential components of the RNA-induced silencing complex (RISC). RISC is responsible for the gene silencing phenomenon...
Small RNA (sRNA) are polymeric RNA molecules that are less than 200 nucleotides in length, and are usually non-coding. RNAsilencing is often a function...
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
RNAsilencing suppressor p19 (also known as Tombusvirus P19 core protein and 19 kDa symptom severity modulator) is a protein expressed from the ORF4 gene...
system of post-transcriptional gene silencing (PTGS) where small interfering RNAs are produced from double-stranded RNA in order to create a sequence specific...
gene silencing. With Andrew Hamilton he discovered the small interfering RNA that is the specificity determinant in RNA-mediated gene silencing. Baulcombe's...
in primary cells that do not divide. siRNAs can also be transfected to achieve RNAsilencing (i.e. loss of RNA and protein from the targeted gene). This...
in RNAsilencing. RNA editing, in which an RNA sequence is altered by a complex of proteins and a "guide RNA", could also be seen as an RNA-to-RNA transfer...
Grimes JM (December 2006). "The structure of an RNAi polymerase links RNAsilencing and transcription". PLoS Biology. 4 (12): e434. doi:10.1371/journal...
RNA polymerase IV (RNAP IV) is an enzyme that synthesizes small interfering RNA (siRNA) in plants, which silence gene expression. RNAP IV belongs to a...
3′-end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component...
transferred, a number of genes coding for RNA-dependent RNA polymerases and other components of RNA-silencing pathways are required, suggesting that paramutation...
hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene...
(3 December 2003). "Recognition of small interfering RNA by a viral suppressor of RNAsilencing". Nature. 426 (6968): 874–878. Bibcode:2003Natur.426....
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