NLK information

NLK
Identifiers
Aliases	NLK, nemo like kinase
External IDs	OMIM: 609476; MGI: 1201387; HomoloGene: 88836; GeneCards: NLK; OMA:NLK - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,196,381 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,588,199 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; retinal pigment epithelium; ; primary visual cortex; ; parietal lobe; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; internal globus pallidus;
	Top expressed in
	Rostral migratory stream; ; retinal pigment epithelium; ; pineal gland; ; prefrontal cortex; ; medial ganglionic eminence; ; habenula; ; olfactory tubercle; ; substantia nigra; ; cumulus cell; ; stria vascularis;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; transcription factor binding; metal ion binding; kinase activity; protein binding; ubiquitin protein ligase binding; protein serine/threonine kinase activity; SH2 domain binding; ATP binding; protein kinase activity; magnesium ion binding; MAP kinase activity;
Cellular component	cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	phosphorylation; protein stabilization; Wnt signaling pathway; transcription, DNA-templated; MAPK cascade; protein autophosphorylation; transforming growth factor beta receptor signaling pathway; Wnt signaling pathway, calcium modulating pathway; regulation of transcription, DNA-templated; negative regulation of Wnt signaling pathway; protein phosphorylation; peptidyl-threonine phosphorylation; regulation of gene expression; serine phosphorylation of STAT protein; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51701
	18099
	ENSG00000087095
	ENSMUSG00000017376
	Q9UBE8
	O54949
	NM_016231
	NM_008702
	NP_057315
	NP_032728
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine protein kinase NLK is an enzyme that in humans is encoded by the NLK gene.^[5]^[6]^[7] Its name is an abbreviation for Nemo-Like Kinase, Nemo (nmo) being the Drosophila ortholog of the mammalian NLK gene.^[8] This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such (it does not even have a numbered MAPK code). It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases (e.g. it does not have the dual phosphorylation motifs of typical MAPKs, and is not phosphorylated by any known MAP2 kinases). Its activation mechanism and downstream targets are still not well characterized.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087095 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017376 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brott BK, Pinsky BA, Erikson RL (Mar 1998). "Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus". Proc Natl Acad Sci U S A. 95 (3): 963–8. Bibcode:1998PNAS...95..963B. doi:10.1073/pnas.95.3.963. PMC 18639. PMID 9448268.
^ Kehrer-Sawatzki H, Moschgath E, Maier C, Legius E, Elgar G, Krone W (Jul 2000). "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts". Gene. 251 (1): 63–71. doi:10.1016/S0378-1119(00)00188-8. PMID 10863097.
^ "Entrez Gene: NLK nemo-like kinase".
^ Ishitani T, Ishitani S (January 2013). "Nemo-like kinase, a multifaceted cell signaling regulator". Cell. Signal. 25 (1): 190–7. doi:10.1016/j.cellsig.2012.09.017. PMID 23000342.
^ Coulombe P, Meloche S (August 2007). "Atypical mitogen-activated protein kinases: structure, regulation and functions". Biochim. Biophys. Acta. 1773 (8): 1376–87. doi:10.1016/j.bbamcr.2006.11.001. PMID 17161475.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087095 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017376 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9448268-5] Brott BK, Pinsky BA, Erikson RL (Mar 1998). "Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus". Proc Natl Acad Sci U S A. 95 (3): 963–8. Bibcode:1998PNAS...95..963B. doi:10.1073/pnas.95.3.963. PMC 18639. PMID 9448268.

[pmid10863097-6] Kehrer-Sawatzki H, Moschgath E, Maier C, Legius E, Elgar G, Krone W (Jul 2000). "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts". Gene. 251 (1): 63–71. doi:10.1016/S0378-1119(00)00188-8. PMID 10863097.

[entrez-7] "Entrez Gene: NLK nemo-like kinase".

[pmid23000342-8] Ishitani T, Ishitani S (January 2013). "Nemo-like kinase, a multifaceted cell signaling regulator". Cell. Signal. 25 (1): 190–7. doi:10.1016/j.cellsig.2012.09.017. PMID 23000342.

[pmid17161475-9] Coulombe P, Meloche S (August 2007). "Atypical mitogen-activated protein kinases: structure, regulation and functions". Biochim. Biophys. Acta. 1773 (8): 1376–87. doi:10.1016/j.bbamcr.2006.11.001. PMID 17161475.

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